Cargando…
Osteopenia of prematurity and associated nutritional factors: case–control study
BACKGROUND: Preterm newborn nutrition affects postnatal skeletal growth and bone mineralization, but studies have not yet fully concluded the relationship between nutrition and osteopenia. This study was intended to investigate the impact of nutritional factors on osteopenia in preterm newborns. MET...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434920/ https://www.ncbi.nlm.nih.gov/pubmed/36050673 http://dx.doi.org/10.1186/s12887-022-03581-y |
_version_ | 1784780992168329216 |
---|---|
author | Pinto, Mônica Raquel Chaves Machado, Márcia Maria Tavares de Azevedo, Daniela Vasconcelos Correia, Luciano Lima Leite, Álvaro Jorge Madeiro Rocha, Hermano Alexandre Lima |
author_facet | Pinto, Mônica Raquel Chaves Machado, Márcia Maria Tavares de Azevedo, Daniela Vasconcelos Correia, Luciano Lima Leite, Álvaro Jorge Madeiro Rocha, Hermano Alexandre Lima |
author_sort | Pinto, Mônica Raquel Chaves |
collection | PubMed |
description | BACKGROUND: Preterm newborn nutrition affects postnatal skeletal growth and bone mineralization, but studies have not yet fully concluded the relationship between nutrition and osteopenia. This study was intended to investigate the impact of nutritional factors on osteopenia in preterm newborns. METHODS: This is a case–control study with babies born with gestational age ≤ 32 weeks in a high-risk maternity hospital, between 2018 and 2019. The population consisted of 115 newborns, being 46 cases (40%) and 69 controls (60%). Disease outcome was based on serum alkaline phosphatase levels > 900UL/l and hypophosphatemia < 4 mg/dl. Gestational data at birth and clinical and nutritional follow-up data during 8 weeks postnatally were assessed. Variables were assessed using regressive logistic models. FINDINGS: Preterm infants who were fed pasteurized fresh human milk with acidity ≥ 4 ºDornic are 5.36 times more likely to develop osteopenia (p = 0.035). Higher calcium intake, compared to controls, also increased the probability of disease occurrence [OR 1.05 (CI 1.006–1.1); p = 0.025], while the presence of a partner [OR 0.10 (CI 0.02–0.59); p = 0.038] and the shortest time using sedatives [OR 0.89 (CI 0.83–0.98); p = 0.010] were protective factors associated with osteopenia. Extremely low birth weight [OR 5.49 (CI 1.20–25.1); p = 0.028], sepsis [OR 5.71 (CI 1.35–24.2); p = 0.018] and invasive ventilatory support [OR 1.09 (CI 1.03–1.18); p = 0.007] were risk factors. CONCLUSIONS: Acidity and high calcium intake are the main nutritional factors associated with osteopenia of prematurity. Further studies on the use of human milk with lower acidity, recommendation and nutritional supplementation of calcium should be accomplished to guide prevention strategies in newborns at risk for osteopenia during hospital stay. |
format | Online Article Text |
id | pubmed-9434920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-94349202022-09-02 Osteopenia of prematurity and associated nutritional factors: case–control study Pinto, Mônica Raquel Chaves Machado, Márcia Maria Tavares de Azevedo, Daniela Vasconcelos Correia, Luciano Lima Leite, Álvaro Jorge Madeiro Rocha, Hermano Alexandre Lima BMC Pediatr Research BACKGROUND: Preterm newborn nutrition affects postnatal skeletal growth and bone mineralization, but studies have not yet fully concluded the relationship between nutrition and osteopenia. This study was intended to investigate the impact of nutritional factors on osteopenia in preterm newborns. METHODS: This is a case–control study with babies born with gestational age ≤ 32 weeks in a high-risk maternity hospital, between 2018 and 2019. The population consisted of 115 newborns, being 46 cases (40%) and 69 controls (60%). Disease outcome was based on serum alkaline phosphatase levels > 900UL/l and hypophosphatemia < 4 mg/dl. Gestational data at birth and clinical and nutritional follow-up data during 8 weeks postnatally were assessed. Variables were assessed using regressive logistic models. FINDINGS: Preterm infants who were fed pasteurized fresh human milk with acidity ≥ 4 ºDornic are 5.36 times more likely to develop osteopenia (p = 0.035). Higher calcium intake, compared to controls, also increased the probability of disease occurrence [OR 1.05 (CI 1.006–1.1); p = 0.025], while the presence of a partner [OR 0.10 (CI 0.02–0.59); p = 0.038] and the shortest time using sedatives [OR 0.89 (CI 0.83–0.98); p = 0.010] were protective factors associated with osteopenia. Extremely low birth weight [OR 5.49 (CI 1.20–25.1); p = 0.028], sepsis [OR 5.71 (CI 1.35–24.2); p = 0.018] and invasive ventilatory support [OR 1.09 (CI 1.03–1.18); p = 0.007] were risk factors. CONCLUSIONS: Acidity and high calcium intake are the main nutritional factors associated with osteopenia of prematurity. Further studies on the use of human milk with lower acidity, recommendation and nutritional supplementation of calcium should be accomplished to guide prevention strategies in newborns at risk for osteopenia during hospital stay. BioMed Central 2022-09-01 /pmc/articles/PMC9434920/ /pubmed/36050673 http://dx.doi.org/10.1186/s12887-022-03581-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Pinto, Mônica Raquel Chaves Machado, Márcia Maria Tavares de Azevedo, Daniela Vasconcelos Correia, Luciano Lima Leite, Álvaro Jorge Madeiro Rocha, Hermano Alexandre Lima Osteopenia of prematurity and associated nutritional factors: case–control study |
title | Osteopenia of prematurity and associated nutritional factors: case–control study |
title_full | Osteopenia of prematurity and associated nutritional factors: case–control study |
title_fullStr | Osteopenia of prematurity and associated nutritional factors: case–control study |
title_full_unstemmed | Osteopenia of prematurity and associated nutritional factors: case–control study |
title_short | Osteopenia of prematurity and associated nutritional factors: case–control study |
title_sort | osteopenia of prematurity and associated nutritional factors: case–control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434920/ https://www.ncbi.nlm.nih.gov/pubmed/36050673 http://dx.doi.org/10.1186/s12887-022-03581-y |
work_keys_str_mv | AT pintomonicaraquelchaves osteopeniaofprematurityandassociatednutritionalfactorscasecontrolstudy AT machadomarciamariatavares osteopeniaofprematurityandassociatednutritionalfactorscasecontrolstudy AT deazevedodanielavasconcelos osteopeniaofprematurityandassociatednutritionalfactorscasecontrolstudy AT correialucianolima osteopeniaofprematurityandassociatednutritionalfactorscasecontrolstudy AT leitealvarojorgemadeiro osteopeniaofprematurityandassociatednutritionalfactorscasecontrolstudy AT rochahermanoalexandrelima osteopeniaofprematurityandassociatednutritionalfactorscasecontrolstudy |