Cargando…

Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis

BACKGROUND: Activation of melanocortin 1 receptor (MC1R) is known to exert broad anti-inflammatory and anti-fibrotic effects. The purpose of this study is to investigate the potential of dersimelagon, a novel oral MC1R agonist, as a therapeutic agent for systemic sclerosis (SSc). METHODS: The effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kondo, Masahiro, Suzuki, Tsuyoshi, Kawano, Yuko, Kojima, Shinji, Miyashiro, Masahiko, Matsumoto, Atsuhiro, Kania, Gabriela, Błyszczuk, Przemysław, Ross, Rebecca L., Mulipa, Panji, Del Galdo, Francesco, Zhang, Yun, Distler, Jörg H. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9434962/ https://www.ncbi.nlm.nih.gov/pubmed/36050717 http://dx.doi.org/10.1186/s13075-022-02899-3

Ejemplares similares

Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist
por: Suzuki, T., et al.
Publicado: (2021)

Absorption, metabolism, and excretion of [ (14)C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers
por: Tsuda, Minoru, et al.
Publicado: (2023)

Results from a first-in-human study of dersimelagon, an investigational oral selective MC1R agonist
por: Ogasawara, Akihito, et al.
Publicado: (2023)

Identification and Isolation of Cardiac Fibroblasts From the Adult Mouse Heart Using Two-Color Flow Cytometry
por: Stellato, Mara, et al.
Publicado: (2019)

SFRP4 Expression Is Linked to Immune-Driven Fibrotic Conditions, Correlates with Skin and Lung Fibrosis in SSc and a Potential EMT Biomarker
por: Tinazzi, Ilaria, et al.
Publicado: (2021)

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease
por: Moscowitz, Anna Elizabeth, et al.
Publicado: (2019)

The AP-1 Transcription Factor Fosl-2 Regulates Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis
por: Seidenberg, Jemima, et al.
Publicado: (2021)

Effects of Melanocortin 1 Receptor Agonists in Experimental Nephropathies
por: Lindskog Jonsson, Annika, et al.
Publicado: (2014)

Editorial: Cutting Edge Methodologies in Experimental Cardiovascular Research
por: Błyszczuk, Przemysław, et al.
Publicado: (2020)

Interactions of the Melanocortin-4 Receptor with the Peptide Agonist NDP-MSH
por: Chapman, Kathryn L., et al.
Publicado: (2010)

Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes
por: Møller, Cathrine Laustrup, et al.
Publicado: (2015)

Demonstration of a Common DPhe(7) to DNal(2′)(7) Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides
por: Gimenez, Luis E., et al.
Publicado: (2022)

Melanocortins, Melanocortin Receptors and Multiple Sclerosis
por: Lisak, Robert P., et al.
Publicado: (2017)

WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts
por: Działo, Edyta, et al.
Publicado: (2019)

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism
por: Błyszczuk, Przemysław, et al.
Publicado: (2020)

Gene Expression Regulation by Agonist-Independent Constitutive Signaling of Melanocortin-1 Receptor
por: Seong, Ikjoo, et al.
Publicado: (2014)

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases
por: Spana, Carl, et al.
Publicado: (2019)

Usefulness of ambulatory blood pressure monitoring to assess the melanocortin receptor agonist bremelanotide
por: White, William B., et al.
Publicado: (2017)

WNT/β-Catenin Signaling Promotes TGF-β-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production
por: Działo, Edyta, et al.
Publicado: (2021)

GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models
por: Gorgogietas, Vyron, et al.
Publicado: (2023)

Effect of setmelanotide, a melanocortin‐4 receptor agonist, on obesity in Bardet‐Biedl syndrome
por: Haws, Robert, et al.
Publicado: (2020)

Pharmacokinetics of the Melanocortin Type 1 Receptor Agonist PL8177 After Subcutaneous Administration
por: Dodd, John, et al.
Publicado: (2021)

Elevated Fibronectin Levels in Profibrotic CD14(+) Monocytes and CD14(+) Macrophages in Systemic Sclerosis
por: Rudnik, Michał, et al.
Publicado: (2021)

Myocarditis in Humans and in Experimental Animal Models
por: Błyszczuk, Przemysław
Publicado: (2019)

A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans
por: Dodd, John, et al.
Publicado: (2023)

T Lymphocyte-Derived Exosomes Transport MEK1/2 and ERK1/2 and Induce NOX4-Dependent Oxidative Stress in Cardiac Microvascular Endothelial Cells
por: Rolski, Filip, et al.
Publicado: (2022)

Melanocortin Regulation of Inflammation
por: Wang, Wei, et al.
Publicado: (2019)

The Multifaceted Melanocortin Receptors
por: Laiho, Linda, et al.
Publicado: (2022)

Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies
por: Rinne, Petteri, et al.
Publicado: (2023)

Haploinsufficient Rock1(+/−) and Rock2(+/−) Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune Myocarditis
por: Tkacz, Karolina, et al.
Publicado: (2020)

Bone phenotype in melanocortin 2 receptor-deficient mice
por: Sato, Tsuyoshi, et al.
Publicado: (2020)

Observations on the Evolution of the Melanocortin Receptor Gene Family: Distinctive Features of the Melanocortin-2 Receptor
por: Dores, Robert M.
Publicado: (2013)

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors
por: Michael, Natalie J., et al.
Publicado: (2020)

Complexity of TNF-α Signaling in Heart Disease
por: Rolski, Filip, et al.
Publicado: (2020)

Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
por: Błyszczuk, Przemysław, et al.
Publicado: (2020)

A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants
por: Huang, Hui, et al.
Publicado: (2014)

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
por: Collet, Tinh-Hai, et al.
Publicado: (2017)

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment
por: Ayers, Kristin L, et al.
Publicado: (2018)

Eicosapentaenoic Acid Ameliorates Non-Alcoholic Steatohepatitis in a Novel Mouse Model Using Melanocortin 4 Receptor-Deficient Mice
por: Konuma, Kuniha, et al.
Publicado: (2015)

Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors
por: Takahashi, Akiyoshi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fjd6q8l25de7uqa7o3kervbdpt