SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals

Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with...

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Autores principales: Sano, Kaori, Bhavsar, Disha, Singh, Gagandeep, Floda, Daniel, Srivastava, Komal, Gleason, Charles, Carreño, Juan Manuel, Simon, Viviana, Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435409/
https://www.ncbi.nlm.nih.gov/pubmed/36050304
http://dx.doi.org/10.1038/s41467-022-32389-8
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author Sano, Kaori
Bhavsar, Disha
Singh, Gagandeep
Floda, Daniel
Srivastava, Komal
Gleason, Charles
Carreño, Juan Manuel
Simon, Viviana
Krammer, Florian
author_facet Sano, Kaori
Bhavsar, Disha
Singh, Gagandeep
Floda, Daniel
Srivastava, Komal
Gleason, Charles
Carreño, Juan Manuel
Simon, Viviana
Krammer, Florian
author_sort Sano, Kaori
collection PubMed
description Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.
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spelling pubmed-94354092022-09-01 SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals Sano, Kaori Bhavsar, Disha Singh, Gagandeep Floda, Daniel Srivastava, Komal Gleason, Charles Carreño, Juan Manuel Simon, Viviana Krammer, Florian Nat Commun Article Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19. Nature Publishing Group UK 2022-09-01 /pmc/articles/PMC9435409/ /pubmed/36050304 http://dx.doi.org/10.1038/s41467-022-32389-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sano, Kaori
Bhavsar, Disha
Singh, Gagandeep
Floda, Daniel
Srivastava, Komal
Gleason, Charles
Carreño, Juan Manuel
Simon, Viviana
Krammer, Florian
SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
title SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
title_full SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
title_fullStr SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
title_full_unstemmed SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
title_short SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals
title_sort sars-cov-2 vaccination induces mucosal antibody responses in previously infected individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435409/
https://www.ncbi.nlm.nih.gov/pubmed/36050304
http://dx.doi.org/10.1038/s41467-022-32389-8
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