Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening

We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with anti-tubercular activity. We selected two series for further explorat...

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Detalles Bibliográficos
Autores principales: Kumar, Anuradha, Chettiar, Somsundaram, Brown, Brian S., Early, Julie, Ollinger, Juliane, Files, Megan, Bailey, Mai A., Korkegian, Aaron, Dennison, Devon, McNeil, Matthew, Metz, James, Osuma, Augustine, Curtin, Michael, Kunzer, Aaron, Freiberg, Gail, Bruncko, Milan, Kempf, Dale, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435431/
https://www.ncbi.nlm.nih.gov/pubmed/36050506
http://dx.doi.org/10.1038/s41598-022-19192-7

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