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EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach
Granulosa cell tumors are uncommon ovarian neoplasms, predominantly of the adult type (AGCT). In this report, we present a rare case of a patient with metastatic AGCT to the stomach diagnosed with endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA). A 61-year-old woman without a history of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435501/ https://www.ncbi.nlm.nih.gov/pubmed/35394548 http://dx.doi.org/10.1093/labmed/lmac024 |
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author | Nikas, Ilias P Sepsa, Athanasia Kleidaradaki, Evangelia Salla, Charitini |
author_facet | Nikas, Ilias P Sepsa, Athanasia Kleidaradaki, Evangelia Salla, Charitini |
author_sort | Nikas, Ilias P |
collection | PubMed |
description | Granulosa cell tumors are uncommon ovarian neoplasms, predominantly of the adult type (AGCT). In this report, we present a rare case of a patient with metastatic AGCT to the stomach diagnosed with endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA). A 61-year-old woman without a history of AGCT underwent both a vaginal and an abdominal ultrasound that showed a solid and cystic ovarian mass along with a solid mass in the gastric antral wall. Subsequently, an EUS-FNA was performed to assess the gastric lesion. Cytologic findings showed high cellularity, and the groups of neoplastic cells invaded the muscle layer of the stomach. Notably, these cells formed Call-Exner bodies, whereas some nuclei exhibited nuclear grooves. Immunohistochemistry was performed, revealing positivity for α-inhibin, calretinin, and CD56 in the neoplastic cells, whereas chromogranin, synaptophysin, CD117, and DOG1 were negative. The combination of clinical presentation, radiology, cytomorphology, and immunohistochemistry could facilitate the diagnosis of metastatic AGCT and the management of such patients. |
format | Online Article Text |
id | pubmed-9435501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94355012022-09-02 EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach Nikas, Ilias P Sepsa, Athanasia Kleidaradaki, Evangelia Salla, Charitini Lab Med Case Study Granulosa cell tumors are uncommon ovarian neoplasms, predominantly of the adult type (AGCT). In this report, we present a rare case of a patient with metastatic AGCT to the stomach diagnosed with endoscopic ultrasound–guided fine-needle aspiration (EUS-FNA). A 61-year-old woman without a history of AGCT underwent both a vaginal and an abdominal ultrasound that showed a solid and cystic ovarian mass along with a solid mass in the gastric antral wall. Subsequently, an EUS-FNA was performed to assess the gastric lesion. Cytologic findings showed high cellularity, and the groups of neoplastic cells invaded the muscle layer of the stomach. Notably, these cells formed Call-Exner bodies, whereas some nuclei exhibited nuclear grooves. Immunohistochemistry was performed, revealing positivity for α-inhibin, calretinin, and CD56 in the neoplastic cells, whereas chromogranin, synaptophysin, CD117, and DOG1 were negative. The combination of clinical presentation, radiology, cytomorphology, and immunohistochemistry could facilitate the diagnosis of metastatic AGCT and the management of such patients. Oxford University Press 2022-04-08 /pmc/articles/PMC9435501/ /pubmed/35394548 http://dx.doi.org/10.1093/labmed/lmac024 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of American Society for Clinical Pathology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Study Nikas, Ilias P Sepsa, Athanasia Kleidaradaki, Evangelia Salla, Charitini EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach |
title | EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach |
title_full | EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach |
title_fullStr | EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach |
title_full_unstemmed | EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach |
title_short | EUS-FNA Diagnosis of a Metastatic Adult Granulosa Cell Tumor in the Stomach |
title_sort | eus-fna diagnosis of a metastatic adult granulosa cell tumor in the stomach |
topic | Case Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9435501/ https://www.ncbi.nlm.nih.gov/pubmed/35394548 http://dx.doi.org/10.1093/labmed/lmac024 |
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