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Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment
BACKGROUND: In patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436028/ https://www.ncbi.nlm.nih.gov/pubmed/36061281 http://dx.doi.org/10.3389/fpsyt.2022.962837 |
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author | Riedlinger, Caroline Mazurak, Nazar Schäffeler, Norbert Stengel, Andreas Giel, Katrin Elisabeth Zipfel, Stephan Enck, Paul Mack, Isabelle |
author_facet | Riedlinger, Caroline Mazurak, Nazar Schäffeler, Norbert Stengel, Andreas Giel, Katrin Elisabeth Zipfel, Stephan Enck, Paul Mack, Isabelle |
author_sort | Riedlinger, Caroline |
collection | PubMed |
description | BACKGROUND: In patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of GI symptoms and their relation to disease-specific, demographic, anthropometric, and psychological factors in inpatients with AN. METHODS: In weekly intervals, the Gastrointestinal Symptom Rating Scale (GSRS) was completed, and body weight was measured over a mean of 9.5 weeks in inpatients with AN. A total of four self-report questionnaires assessing psychological factors were completed before and after inpatient treatment. Data from 38 inpatients with AN were analyzed using mixed linear models. RESULTS: Abdominal pain and constipation improved significantly in the timecourse with 0.085 (p = 0.002) and 0.101 (p = 0.004) points per week on the GSRS and were predicted to normalize after 13 (p = 0.002) and 17 (p = 0.004) weeks, respectively. Total GI symptoms tended to normalize after 25 weeks (p = 0.079). Indigestion (borborygmus, abdominal distension, eructation, flatulence) was the most severely pathological symptom at admission and did not improve significantly (p = 0.197). Diarrhea and reflux were, on average, not pathological at admission and remained stable during treatment. In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation. CONCLUSIONS: Informing patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment. |
format | Online Article Text |
id | pubmed-9436028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94360282022-09-02 Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment Riedlinger, Caroline Mazurak, Nazar Schäffeler, Norbert Stengel, Andreas Giel, Katrin Elisabeth Zipfel, Stephan Enck, Paul Mack, Isabelle Front Psychiatry Psychiatry BACKGROUND: In patients with anorexia nervosa (AN), gastrointestinal (GI) symptoms are common and usually improve during or after nutritional rehabilitation. It is unclear when exactly GI symptoms change in the timecourse of treatment and to which extent. In this study, we analyzed the timecourse of GI symptoms and their relation to disease-specific, demographic, anthropometric, and psychological factors in inpatients with AN. METHODS: In weekly intervals, the Gastrointestinal Symptom Rating Scale (GSRS) was completed, and body weight was measured over a mean of 9.5 weeks in inpatients with AN. A total of four self-report questionnaires assessing psychological factors were completed before and after inpatient treatment. Data from 38 inpatients with AN were analyzed using mixed linear models. RESULTS: Abdominal pain and constipation improved significantly in the timecourse with 0.085 (p = 0.002) and 0.101 (p = 0.004) points per week on the GSRS and were predicted to normalize after 13 (p = 0.002) and 17 (p = 0.004) weeks, respectively. Total GI symptoms tended to normalize after 25 weeks (p = 0.079). Indigestion (borborygmus, abdominal distension, eructation, flatulence) was the most severely pathological symptom at admission and did not improve significantly (p = 0.197). Diarrhea and reflux were, on average, not pathological at admission and remained stable during treatment. In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation. CONCLUSIONS: Informing patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9436028/ /pubmed/36061281 http://dx.doi.org/10.3389/fpsyt.2022.962837 Text en Copyright © 2022 Riedlinger, Mazurak, Schäffeler, Stengel, Giel, Zipfel, Enck and Mack. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Riedlinger, Caroline Mazurak, Nazar Schäffeler, Norbert Stengel, Andreas Giel, Katrin Elisabeth Zipfel, Stephan Enck, Paul Mack, Isabelle Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
title | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
title_full | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
title_fullStr | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
title_full_unstemmed | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
title_short | Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
title_sort | gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436028/ https://www.ncbi.nlm.nih.gov/pubmed/36061281 http://dx.doi.org/10.3389/fpsyt.2022.962837 |
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