A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation

The class I histone deacetylases are essential regulators of cell fate decisions in health and disease. While pan- and class-specific HDAC inhibitors are available, these drugs do not allow a comprehensive understanding of individual HDAC function, or the therapeutic potential of isoform-specific ta...

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Detalles Bibliográficos
Autores principales: Hess, Lena, Moos, Verena, Lauber, Arnel A., Reiter, Wolfgang, Schuster, Michael, Hartl, Natascha, Lackner, Daniel, Boenke, Thorina, Koren, Anna, Guzzardo, Paloma M., Gundacker, Brigitte, Riegler, Anna, Vician, Petra, Miccolo, Claudia, Leiter, Susanna, Chandrasekharan, Mahesh B., Vcelkova, Terezia, Tanzer, Andrea, Jun, Jun Qi, Bradner, James, Brosch, Gerald, Hartl, Markus, Bock, Christoph, Bürckstümmer, Tilmann, Kubicek, Stefan, Chiocca, Susanna, Bhaskara, Srividya, Seiser, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436093/
https://www.ncbi.nlm.nih.gov/pubmed/35994477
http://dx.doi.org/10.1371/journal.pgen.1010376

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