PGRS domain structures: Doomed to sail the mycomembrane

The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS “sailing” model as a smart tool to diffuse along the mycomembrane,...

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Detalles Bibliográficos
Autores principales: Berisio, Rita, Delogu, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436101/
https://www.ncbi.nlm.nih.gov/pubmed/36048802
http://dx.doi.org/10.1371/journal.ppat.1010760
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author Berisio, Rita
Delogu, Giovanni
author_facet Berisio, Rita
Delogu, Giovanni
author_sort Berisio, Rita
collection PubMed
description The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS “sailing” model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.
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spelling pubmed-94361012022-09-02 PGRS domain structures: Doomed to sail the mycomembrane Berisio, Rita Delogu, Giovanni PLoS Pathog Opinion The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS “sailing” model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus. Public Library of Science 2022-09-01 /pmc/articles/PMC9436101/ /pubmed/36048802 http://dx.doi.org/10.1371/journal.ppat.1010760 Text en © 2022 Berisio, Delogu https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Opinion
Berisio, Rita
Delogu, Giovanni
PGRS domain structures: Doomed to sail the mycomembrane
title PGRS domain structures: Doomed to sail the mycomembrane
title_full PGRS domain structures: Doomed to sail the mycomembrane
title_fullStr PGRS domain structures: Doomed to sail the mycomembrane
title_full_unstemmed PGRS domain structures: Doomed to sail the mycomembrane
title_short PGRS domain structures: Doomed to sail the mycomembrane
title_sort pgrs domain structures: doomed to sail the mycomembrane
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436101/
https://www.ncbi.nlm.nih.gov/pubmed/36048802
http://dx.doi.org/10.1371/journal.ppat.1010760
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