Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn(2+)-dependent amidases

Human alkaline ceramidase 3 (ACER3) is one of three alkaline ceramidases (ACERs) that catalyze the conversion of ceramide to sphingosine. ACERs are members of the CREST superfamily of integral-membrane hydrolases. All CREST members conserve a set of three Histidine, one Aspartate, and one Serine res...

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Detalles Bibliográficos
Autores principales: Yi, Jae Kyo, Xu, Ruijuan, Obeid, Lina M., Hannun, Yusuf A., Airola, Michael V., Mao, Cungui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436119/
https://www.ncbi.nlm.nih.gov/pubmed/36048828
http://dx.doi.org/10.1371/journal.pone.0271540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436119/
https://www.ncbi.nlm.nih.gov/pubmed/36048828
http://dx.doi.org/10.1371/journal.pone.0271540

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