Reduced sister chromatid cohesion acts as a tumor penetrance modifier

Sister chromatid cohesion (SCC) is an important process in chromosome segregation. ESCO2 is essential for establishment of SCC and is often deleted/altered in human cancers. We demonstrate that esco2 haploinsufficiency results in reduced SCC and accelerates the timing of tumor onset in both zebrafis...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Thomas, Holly R., Chen, Yu, Percival, Stefanie M., Waldrep, Stephanie C., Ramaker, Ryne C., Thompson, Robert G., Cooper, Sara J., Chong, Zechen, Parant, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436123/
https://www.ncbi.nlm.nih.gov/pubmed/35994499
http://dx.doi.org/10.1371/journal.pgen.1010341

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