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Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation

Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of B. monnieri extracts (BME), focusing on anti-cancer and neurodegenerativ...

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Autores principales: Fatima, Urooj, Roy, Sonam, Ahmad, Shahnawaz, Ali, Sabeeha, Elkady, Wafaa M., Khan, Ilyas, Alsaffar, Rana M., Adnan, Mohd, Islam, Asimul, Hassan, Md. Imtaiyaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436272/
https://www.ncbi.nlm.nih.gov/pubmed/36061899
http://dx.doi.org/10.3389/fnut.2022.972379
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author Fatima, Urooj
Roy, Sonam
Ahmad, Shahnawaz
Ali, Sabeeha
Elkady, Wafaa M.
Khan, Ilyas
Alsaffar, Rana M.
Adnan, Mohd
Islam, Asimul
Hassan, Md. Imtaiyaz
author_facet Fatima, Urooj
Roy, Sonam
Ahmad, Shahnawaz
Ali, Sabeeha
Elkady, Wafaa M.
Khan, Ilyas
Alsaffar, Rana M.
Adnan, Mohd
Islam, Asimul
Hassan, Md. Imtaiyaz
author_sort Fatima, Urooj
collection PubMed
description Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of B. monnieri extracts (BME), focusing on anti-cancer and neurodegenerative diseases. We examined the clinical studies on phytochemistry and pharmacological application of BME. We further highlighted the mechanism of action of these extracts in varying types of cancer and their therapeutic implications. In addition, we investigated the underlying molecular mechanism in therapeutic interventions, toxicities, safety concerns and synergistic potential in cognition and neuroprotection. Overall, this review provides deeper insights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects.
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spelling pubmed-94362722022-09-02 Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation Fatima, Urooj Roy, Sonam Ahmad, Shahnawaz Ali, Sabeeha Elkady, Wafaa M. Khan, Ilyas Alsaffar, Rana M. Adnan, Mohd Islam, Asimul Hassan, Md. Imtaiyaz Front Nutr Nutrition Bacopa monnieri has been used for centuries in Ayurvedic medicine, alone or in combination with other herbs, as a memory and learning enhancer, sedative, and anti-epileptic. This review aimed to highlight the health benefits of B. monnieri extracts (BME), focusing on anti-cancer and neurodegenerative diseases. We examined the clinical studies on phytochemistry and pharmacological application of BME. We further highlighted the mechanism of action of these extracts in varying types of cancer and their therapeutic implications. In addition, we investigated the underlying molecular mechanism in therapeutic interventions, toxicities, safety concerns and synergistic potential in cognition and neuroprotection. Overall, this review provides deeper insights into the therapeutic implications of Brahmi as a lead formulation for treating neurological disorders and exerting cognitive-enhancing effects. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9436272/ /pubmed/36061899 http://dx.doi.org/10.3389/fnut.2022.972379 Text en Copyright © 2022 Fatima, Roy, Ahmad, Ali, Elkady, Khan, Alsaffar, Adnan, Islam and Hassan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Fatima, Urooj
Roy, Sonam
Ahmad, Shahnawaz
Ali, Sabeeha
Elkady, Wafaa M.
Khan, Ilyas
Alsaffar, Rana M.
Adnan, Mohd
Islam, Asimul
Hassan, Md. Imtaiyaz
Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
title Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
title_full Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
title_fullStr Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
title_full_unstemmed Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
title_short Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
title_sort pharmacological attributes of bacopa monnieri extract: current updates and clinical manifestation
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436272/
https://www.ncbi.nlm.nih.gov/pubmed/36061899
http://dx.doi.org/10.3389/fnut.2022.972379
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