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Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study

BACKGROUND AND AIMS: Female fertility is a heterogeneous condition of complete psychosocial and physical well‐being. Observational studies have revealed that women with infertility have varying degrees of poor mental status and lifestyle choices in varying degrees. However, the genetic contribution...

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Autores principales: Ma, Miao, Guo, Lu, Liu, Xiaocheng, Zheng, Yingxin, Gu, Chao, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436294/
https://www.ncbi.nlm.nih.gov/pubmed/36090619
http://dx.doi.org/10.1002/hsr2.797
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author Ma, Miao
Guo, Lu
Liu, Xiaocheng
Zheng, Yingxin
Gu, Chao
Li, Bin
author_facet Ma, Miao
Guo, Lu
Liu, Xiaocheng
Zheng, Yingxin
Gu, Chao
Li, Bin
author_sort Ma, Miao
collection PubMed
description BACKGROUND AND AIMS: Female fertility is a heterogeneous condition of complete psychosocial and physical well‐being. Observational studies have revealed that women with infertility have varying degrees of poor mental status and lifestyle choices in varying degrees. However, the genetic contribution to female infertility remains elusive. Our study aimed to explore the genetic correlations between female infertility and mental health and lifestyle factors. METHODS: The genome‐wide association study (GWAS) data sets of characteristics related to mental health and lifestyle were obtained from the IEU OpenGWAS database. The GWAS data sets of female infertility were derived from the Finggen database. Linkage disequilibrium score regression was performed to systematically estimate the pairwise genetic correlations between female infertility and a set of mental health‐ and lifestyle‐related traits. RESULTS: The genetic correlation analysis revealed a moderate and positive genetic correlation between depressive symptoms, major depressive disorder, and female infertility. Similarly, worry and the personality trait of neuroticism displayed a moderate positive genetic correlation with female infertility. Adversely, a negative and moderate genetic correlation was observed between strenuous sports or exercises and female infertility. CONCLUSION: The study demonstrated genetic correlations between female infertility and mental health status, including depression, worry, and neuroticism. Additionally, we observed that females with better physical activity may have reduced risks of female infertility. These findings would serve as a fundamental resource for understanding the genetic mechanisms of the effects of mental health and lifestyle factors on female infertility.
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spelling pubmed-94362942022-09-09 Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study Ma, Miao Guo, Lu Liu, Xiaocheng Zheng, Yingxin Gu, Chao Li, Bin Health Sci Rep Original Research BACKGROUND AND AIMS: Female fertility is a heterogeneous condition of complete psychosocial and physical well‐being. Observational studies have revealed that women with infertility have varying degrees of poor mental status and lifestyle choices in varying degrees. However, the genetic contribution to female infertility remains elusive. Our study aimed to explore the genetic correlations between female infertility and mental health and lifestyle factors. METHODS: The genome‐wide association study (GWAS) data sets of characteristics related to mental health and lifestyle were obtained from the IEU OpenGWAS database. The GWAS data sets of female infertility were derived from the Finggen database. Linkage disequilibrium score regression was performed to systematically estimate the pairwise genetic correlations between female infertility and a set of mental health‐ and lifestyle‐related traits. RESULTS: The genetic correlation analysis revealed a moderate and positive genetic correlation between depressive symptoms, major depressive disorder, and female infertility. Similarly, worry and the personality trait of neuroticism displayed a moderate positive genetic correlation with female infertility. Adversely, a negative and moderate genetic correlation was observed between strenuous sports or exercises and female infertility. CONCLUSION: The study demonstrated genetic correlations between female infertility and mental health status, including depression, worry, and neuroticism. Additionally, we observed that females with better physical activity may have reduced risks of female infertility. These findings would serve as a fundamental resource for understanding the genetic mechanisms of the effects of mental health and lifestyle factors on female infertility. John Wiley and Sons Inc. 2022-09-01 /pmc/articles/PMC9436294/ /pubmed/36090619 http://dx.doi.org/10.1002/hsr2.797 Text en © 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Ma, Miao
Guo, Lu
Liu, Xiaocheng
Zheng, Yingxin
Gu, Chao
Li, Bin
Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study
title Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study
title_full Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study
title_fullStr Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study
title_full_unstemmed Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study
title_short Genetic correlation between female infertility and mental health and lifestyle factors: A linkage disequilibrium score regression study
title_sort genetic correlation between female infertility and mental health and lifestyle factors: a linkage disequilibrium score regression study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436294/
https://www.ncbi.nlm.nih.gov/pubmed/36090619
http://dx.doi.org/10.1002/hsr2.797
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