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Scalp HFO rates are higher for larger lesions
High‐frequency oscillations (HFO) in scalp EEG are a new and promising noninvasive epilepsy biomarker, providing added prognostic value, particularly in pediatric lesional epilepsy. However, it is unclear if lesion characteristics, such as lesion volume, depth, type, and localization, impact scalp H...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436296/ https://www.ncbi.nlm.nih.gov/pubmed/35357778 http://dx.doi.org/10.1002/epi4.12596 |
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author | Cserpan, Dorottya Gennari, Antonio Gaito, Luca Lo Biundo, Santo Pietro Tuura, Ruth Sarnthein, Johannes Ramantani, Georgia |
author_facet | Cserpan, Dorottya Gennari, Antonio Gaito, Luca Lo Biundo, Santo Pietro Tuura, Ruth Sarnthein, Johannes Ramantani, Georgia |
author_sort | Cserpan, Dorottya |
collection | PubMed |
description | High‐frequency oscillations (HFO) in scalp EEG are a new and promising noninvasive epilepsy biomarker, providing added prognostic value, particularly in pediatric lesional epilepsy. However, it is unclear if lesion characteristics, such as lesion volume, depth, type, and localization, impact scalp HFO rates. We analyzed scalp EEG from 13 children and adolescents with focal epilepsy associated with focal cortical dysplasia (FCD), low‐grade tumors, or hippocampal sclerosis. We applied a validated automated detector to determine HFO rates in bipolar channels. We identified the lesion characteristics in MRI. Larger lesions defined by MRI volumetric analysis corresponded to higher cumulative scalp HFO rates (P = .01) that were detectable in a higher number of channels (P = .05). Both superficial and deep lesions generated HFO detectable in the scalp EEG. Lesion type (FCD vs tumor) and lobar localization (temporal vs extratemporal) did not affect scalp HFO rates in our study. Our observations support that all lesions may generate HFO detectable in scalp EEG, irrespective of their characteristics, whereas larger epileptogenic lesions generate higher scalp HFO rates over larger areas that are thus more accessible to detection. Our study provides crucial insight into scalp HFO detectability in pediatric lesional epilepsy, facilitating their implementation as an epilepsy biomarker in a clinical setting. |
format | Online Article Text |
id | pubmed-9436296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94362962022-09-09 Scalp HFO rates are higher for larger lesions Cserpan, Dorottya Gennari, Antonio Gaito, Luca Lo Biundo, Santo Pietro Tuura, Ruth Sarnthein, Johannes Ramantani, Georgia Epilepsia Open Short Research Articles High‐frequency oscillations (HFO) in scalp EEG are a new and promising noninvasive epilepsy biomarker, providing added prognostic value, particularly in pediatric lesional epilepsy. However, it is unclear if lesion characteristics, such as lesion volume, depth, type, and localization, impact scalp HFO rates. We analyzed scalp EEG from 13 children and adolescents with focal epilepsy associated with focal cortical dysplasia (FCD), low‐grade tumors, or hippocampal sclerosis. We applied a validated automated detector to determine HFO rates in bipolar channels. We identified the lesion characteristics in MRI. Larger lesions defined by MRI volumetric analysis corresponded to higher cumulative scalp HFO rates (P = .01) that were detectable in a higher number of channels (P = .05). Both superficial and deep lesions generated HFO detectable in the scalp EEG. Lesion type (FCD vs tumor) and lobar localization (temporal vs extratemporal) did not affect scalp HFO rates in our study. Our observations support that all lesions may generate HFO detectable in scalp EEG, irrespective of their characteristics, whereas larger epileptogenic lesions generate higher scalp HFO rates over larger areas that are thus more accessible to detection. Our study provides crucial insight into scalp HFO detectability in pediatric lesional epilepsy, facilitating their implementation as an epilepsy biomarker in a clinical setting. John Wiley and Sons Inc. 2022-05-06 /pmc/articles/PMC9436296/ /pubmed/35357778 http://dx.doi.org/10.1002/epi4.12596 Text en © 2022 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Short Research Articles Cserpan, Dorottya Gennari, Antonio Gaito, Luca Lo Biundo, Santo Pietro Tuura, Ruth Sarnthein, Johannes Ramantani, Georgia Scalp HFO rates are higher for larger lesions |
title | Scalp HFO rates are higher for larger lesions |
title_full | Scalp HFO rates are higher for larger lesions |
title_fullStr | Scalp HFO rates are higher for larger lesions |
title_full_unstemmed | Scalp HFO rates are higher for larger lesions |
title_short | Scalp HFO rates are higher for larger lesions |
title_sort | scalp hfo rates are higher for larger lesions |
topic | Short Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436296/ https://www.ncbi.nlm.nih.gov/pubmed/35357778 http://dx.doi.org/10.1002/epi4.12596 |
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