The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages

GCN2 (general control nonderepressible 2) is a serine/threonine-protein kinase that controls messenger RNA translation in response to amino acid availability and ribosome stalling. Here, we show that GCN2 controls erythrocyte clearance and iron recycling during stress. Our data highlight the importa...

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Detalles Bibliográficos
Autores principales: Toboz, Phoenix, Amiri, Mehdi, Tabatabaei, Negar, Dufour, Catherine R., Kim, Seung Hyeon, Fillebeen, Carine, Ayemoba, Charles E., Khoutorsky, Arkady, Nairz, Manfred, Shao, Lijian, Pajcini, Kostandin V., Kim, Ki-Wook, Giguère, Vincent, Oliveira, Regiana L., Constante, Marco, Santos, Manuela M., Morales, Carlos R., Pantopoulos, Kostas, Sonenberg, Nahum, Pinho, Sandra, Tahmasebi, Soroush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436309/
https://www.ncbi.nlm.nih.gov/pubmed/35994670
http://dx.doi.org/10.1073/pnas.2121251119

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