Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain

The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon death and is a possible therapeutic target for neurodegenerative disorders. While orthosteric inhibitors of SARM1 have been des...

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Detalles Bibliográficos
Autores principales: Feldman, Hannah C., Merlini, Elisa, Guijas, Carlos, DeMeester, Kristen E., Njomen, Evert, Kozina, Ellen M., Yokoyama, Minoru, Vinogradova, Ekaterina, Reardon, Holly T., Melillo, Bruno, Schreiber, Stuart L., Loreto, Andrea, Blankman, Jacqueline L., Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436332/
https://www.ncbi.nlm.nih.gov/pubmed/35994671
http://dx.doi.org/10.1073/pnas.2208457119

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