Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients

Narcolepsy type 1 (NT1) is a sleep disorder caused by a loss of orexinergic neurons. Narcolepsy type 2 (NT2) is heterogeneous; affected individuals typically have normal orexin levels. Following evaluation in mice, the effects of the orexin 2 receptor (OX2R)-selective agonist danavorexton were evalu...

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Detalles Bibliográficos
Autores principales: Evans, Rebecca, Kimura, Haruhide, Alexander, Robert, Davies, Ceri H., Faessel, Hélène, Hartman, Deborah S., Ishikawa, Takashi, Ratti, Emiliangelo, Shimizu, Kohei, Suzuki, Motohisa, Tanaka, Shinichiro, Yukitake, Hiroshi, Dauvilliers, Yves, Mignot, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436334/
https://www.ncbi.nlm.nih.gov/pubmed/35994639
http://dx.doi.org/10.1073/pnas.2207531119

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