SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for neutralizing antibodies (NAbs). The S protein trimer is anchored in the virion membrane in its prefusion (preS) but metastable form. The preS protein has been stabilized by introducing two or...

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Detalles Bibliográficos
Autores principales: Lu, Mijia, Chamblee, Michelle, Zhang, Yuexiu, Ye, Chengjin, Dravid, Piyush, Park, Jun-Gyu, Mahesh, KC, Trivedi, Sheetal, Murthy, Satyapramod, Sharma, Himanshu, Cassady, Cole, Chaiwatpongsakorn, Supranee, Liang, Xueya, Yount, Jacob S., Boyaka, Prosper N., Peeples, Mark E., Martinez-Sobrido, Luis, Kapoor, Amit, Li, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436349/
https://www.ncbi.nlm.nih.gov/pubmed/35994646
http://dx.doi.org/10.1073/pnas.2110105119

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