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The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia

Artemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica...

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Autores principales: Cui, Zhanhu, Li, Siqi, Chang, Jiayin, Zang, Erhuan, Liu, Qian, Zhou, Baochang, Li, Chao, Li, Mengzhi, Huang, Xianzhang, Zhang, Zhongyi, Li, Minhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436419/
https://www.ncbi.nlm.nih.gov/pubmed/36061795
http://dx.doi.org/10.3389/fpls.2022.949743
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author Cui, Zhanhu
Li, Siqi
Chang, Jiayin
Zang, Erhuan
Liu, Qian
Zhou, Baochang
Li, Chao
Li, Mengzhi
Huang, Xianzhang
Zhang, Zhongyi
Li, Minhui
author_facet Cui, Zhanhu
Li, Siqi
Chang, Jiayin
Zang, Erhuan
Liu, Qian
Zhou, Baochang
Li, Chao
Li, Mengzhi
Huang, Xianzhang
Zhang, Zhongyi
Li, Minhui
author_sort Cui, Zhanhu
collection PubMed
description Artemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica in China and a phylogenetic tree of common medicinal plants in Asteraceae. Then, we verified the chemical composition changes of A. argyi and A. indica via their metabolome. Traditional efficacy and modern pharmacological action were verified by network pharmacology and in vitro using RAW264.7 cells. The results showed that A. argyi and A. indica are widely distributed in China, and they shared pharmaphylogeny, which provides theoretical support for the mixed use of A. argyi and A. indica in most regions of China. Furthermore, there were both similarities and differences in volatile oil and flavonoid composition between A. argyi and A. indica. The network pharmacology results showed that A. argyi and A. indica had 23 common active compounds and that both had pharmacological effects on chronic gastritis (CG). Molecular docking analyses showed that quercetin, luteolin, and kaempferol have strong binding affinities with the target proteins JUN, TP53, AKT1, MAPK3, TNF, MAPK, and IL6. The cell experiment results further demonstrated that A. argyi and A. indica treat CG via the NOD-like receptor pathway. Based on the theory of pharmaphylogeny, this study explored the pharmaphylogeny between A. argyi and A. indica from various perspectives to provide a basis for the substitution of A. argyi and A. indica.
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spelling pubmed-94364192022-09-02 The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia Cui, Zhanhu Li, Siqi Chang, Jiayin Zang, Erhuan Liu, Qian Zhou, Baochang Li, Chao Li, Mengzhi Huang, Xianzhang Zhang, Zhongyi Li, Minhui Front Plant Sci Plant Science Artemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica in China and a phylogenetic tree of common medicinal plants in Asteraceae. Then, we verified the chemical composition changes of A. argyi and A. indica via their metabolome. Traditional efficacy and modern pharmacological action were verified by network pharmacology and in vitro using RAW264.7 cells. The results showed that A. argyi and A. indica are widely distributed in China, and they shared pharmaphylogeny, which provides theoretical support for the mixed use of A. argyi and A. indica in most regions of China. Furthermore, there were both similarities and differences in volatile oil and flavonoid composition between A. argyi and A. indica. The network pharmacology results showed that A. argyi and A. indica had 23 common active compounds and that both had pharmacological effects on chronic gastritis (CG). Molecular docking analyses showed that quercetin, luteolin, and kaempferol have strong binding affinities with the target proteins JUN, TP53, AKT1, MAPK3, TNF, MAPK, and IL6. The cell experiment results further demonstrated that A. argyi and A. indica treat CG via the NOD-like receptor pathway. Based on the theory of pharmaphylogeny, this study explored the pharmaphylogeny between A. argyi and A. indica from various perspectives to provide a basis for the substitution of A. argyi and A. indica. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9436419/ /pubmed/36061795 http://dx.doi.org/10.3389/fpls.2022.949743 Text en Copyright © 2022 Cui, Li, Chang, Zang, Liu, Zhou, Li, Li, Huang, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Cui, Zhanhu
Li, Siqi
Chang, Jiayin
Zang, Erhuan
Liu, Qian
Zhou, Baochang
Li, Chao
Li, Mengzhi
Huang, Xianzhang
Zhang, Zhongyi
Li, Minhui
The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
title The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
title_full The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
title_fullStr The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
title_full_unstemmed The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
title_short The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
title_sort pharmacophylogenetic relationships of two edible medicinal plants in the genus artemisia
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436419/
https://www.ncbi.nlm.nih.gov/pubmed/36061795
http://dx.doi.org/10.3389/fpls.2022.949743
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