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The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease
Introduction The exact mechanisms of obesity-related kidney disease (ORKD) are not fully known. Heat shock proteins (HSPs) may play a role in ORKD mechanisms because of their role in cell apoptosis, cytoprotection, and inflammatory processes. We aimed to determine the role of circulating serum HSP-6...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436442/ https://www.ncbi.nlm.nih.gov/pubmed/36062294 http://dx.doi.org/10.7759/cureus.28675 |
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author | Yıldırım, Özden Tatar, Erhan |
author_facet | Yıldırım, Özden Tatar, Erhan |
author_sort | Yıldırım, Özden |
collection | PubMed |
description | Introduction The exact mechanisms of obesity-related kidney disease (ORKD) are not fully known. Heat shock proteins (HSPs) may play a role in ORKD mechanisms because of their role in cell apoptosis, cytoprotection, and inflammatory processes. We aimed to determine the role of circulating serum HSP-60 and HSP-70 levels as a biomarker for ORKD. Materials and methods This study included 40 ORKD patients, 40 obese age-matched and sex-matched controls with similar body mass index (BMI), and 40 healthy controls. Their serum biochemical and hemogram parameters as well as HSP-60 and HSP-70 levels were evaluated and compared. Their neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein levels were assessed to define inflammation. Results The patients had significantly higher HSP-60 levels than the obese and healthy controls (537.58 ± 170.35, 430.80 ± 110.61, and 371.85 ± 76.34, respectively; p<0.00). The results revealed that the 24-hour urinary protein levels had a positive correlation (r= 0.544), whereas the glomerular filtration rate had a negative correlation (r = 0.38) with the serum HSP-60 level. According to the regression analysis performed on the HSP-60 and 24-hour urinary protein excretion levels, an increase in the HSP-60 level significantly increased the 24-hour urinary protein excretion rate (r=0.15; p<0.005). The HSP-60 levels were correlated with inflammatory markers Conclusion The serum HSP-60 levels increased in patients with ORKD. This increase was correlated with 24-hour urinary protein excretion. Increased circulating levels of HSP-60 may play a role in the initiation and/or progression of renal damage and inflammation. HSP-60 is a potential biomarker for ORKD. However, additional information and studies are required to further elucidate this finding. |
format | Online Article Text |
id | pubmed-9436442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-94364422022-09-03 The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease Yıldırım, Özden Tatar, Erhan Cureus Endocrinology/Diabetes/Metabolism Introduction The exact mechanisms of obesity-related kidney disease (ORKD) are not fully known. Heat shock proteins (HSPs) may play a role in ORKD mechanisms because of their role in cell apoptosis, cytoprotection, and inflammatory processes. We aimed to determine the role of circulating serum HSP-60 and HSP-70 levels as a biomarker for ORKD. Materials and methods This study included 40 ORKD patients, 40 obese age-matched and sex-matched controls with similar body mass index (BMI), and 40 healthy controls. Their serum biochemical and hemogram parameters as well as HSP-60 and HSP-70 levels were evaluated and compared. Their neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein levels were assessed to define inflammation. Results The patients had significantly higher HSP-60 levels than the obese and healthy controls (537.58 ± 170.35, 430.80 ± 110.61, and 371.85 ± 76.34, respectively; p<0.00). The results revealed that the 24-hour urinary protein levels had a positive correlation (r= 0.544), whereas the glomerular filtration rate had a negative correlation (r = 0.38) with the serum HSP-60 level. According to the regression analysis performed on the HSP-60 and 24-hour urinary protein excretion levels, an increase in the HSP-60 level significantly increased the 24-hour urinary protein excretion rate (r=0.15; p<0.005). The HSP-60 levels were correlated with inflammatory markers Conclusion The serum HSP-60 levels increased in patients with ORKD. This increase was correlated with 24-hour urinary protein excretion. Increased circulating levels of HSP-60 may play a role in the initiation and/or progression of renal damage and inflammation. HSP-60 is a potential biomarker for ORKD. However, additional information and studies are required to further elucidate this finding. Cureus 2022-09-01 /pmc/articles/PMC9436442/ /pubmed/36062294 http://dx.doi.org/10.7759/cureus.28675 Text en Copyright © 2022, Yıldırım et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Yıldırım, Özden Tatar, Erhan The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease |
title | The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease |
title_full | The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease |
title_fullStr | The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease |
title_full_unstemmed | The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease |
title_short | The Roles of Heat Shock Protein-60 and 70 and Inflammation in Obesity-Related Kidney Disease |
title_sort | roles of heat shock protein-60 and 70 and inflammation in obesity-related kidney disease |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436442/ https://www.ncbi.nlm.nih.gov/pubmed/36062294 http://dx.doi.org/10.7759/cureus.28675 |
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