SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4(+) T cells

Type I interferons (type I-IFN) are critical for the host defense to viral infection, and at the same time, the dysregulation of type I-IFN responses leads to autoinflammation or autoimmunity. Recently, we reported that the decrease in monounsaturated fatty acid caused by the genetic deletion of Scd...

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Detalles Bibliográficos
Autores principales: Kanno, Toshio, Miyako, Keisuke, Nakajima, Takahiro, Yokoyama, Satoru, Sasamoto, Shigemi, Asou, Hikari K., Ohara, Osamu, Nakayama, Toshinori, Endo, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436477/
https://www.ncbi.nlm.nih.gov/pubmed/36059459
http://dx.doi.org/10.3389/fimmu.2022.904875

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