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SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition

Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing ev...

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Autores principales: Strýčková, Alena, Benko, Jakub, Péč, Martin Jozef, Péčová, Monika, Žolková, Jana, Brunclíková, Monika, Bolek, Tomáš, Staško, Ján, Samoš, Matej, Mokáň, Marián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436625/
https://www.ncbi.nlm.nih.gov/pubmed/36060118
http://dx.doi.org/10.1155/2022/7805900
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author Strýčková, Alena
Benko, Jakub
Péč, Martin Jozef
Péčová, Monika
Žolková, Jana
Brunclíková, Monika
Bolek, Tomáš
Staško, Ján
Samoš, Matej
Mokáň, Marián
author_facet Strýčková, Alena
Benko, Jakub
Péč, Martin Jozef
Péčová, Monika
Žolková, Jana
Brunclíková, Monika
Bolek, Tomáš
Staško, Ján
Samoš, Matej
Mokáň, Marián
author_sort Strýčková, Alena
collection PubMed
description Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.
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spelling pubmed-94366252022-09-02 SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition Strýčková, Alena Benko, Jakub Péč, Martin Jozef Péčová, Monika Žolková, Jana Brunclíková, Monika Bolek, Tomáš Staško, Ján Samoš, Matej Mokáň, Marián Case Rep Hematol Case Report Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients. Hindawi 2022-08-25 /pmc/articles/PMC9436625/ /pubmed/36060118 http://dx.doi.org/10.1155/2022/7805900 Text en Copyright © 2022 Alena Strýčková et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Strýčková, Alena
Benko, Jakub
Péč, Martin Jozef
Péčová, Monika
Žolková, Jana
Brunclíková, Monika
Bolek, Tomáš
Staško, Ján
Samoš, Matej
Mokáň, Marián
SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
title SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
title_full SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
title_fullStr SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
title_full_unstemmed SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
title_short SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
title_sort sars-cov-2 infection-associated aortic thrombosis treated with oral factor xa inhibition
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436625/
https://www.ncbi.nlm.nih.gov/pubmed/36060118
http://dx.doi.org/10.1155/2022/7805900
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