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SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing ev...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436625/ https://www.ncbi.nlm.nih.gov/pubmed/36060118 http://dx.doi.org/10.1155/2022/7805900 |
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author | Strýčková, Alena Benko, Jakub Péč, Martin Jozef Péčová, Monika Žolková, Jana Brunclíková, Monika Bolek, Tomáš Staško, Ján Samoš, Matej Mokáň, Marián |
author_facet | Strýčková, Alena Benko, Jakub Péč, Martin Jozef Péčová, Monika Žolková, Jana Brunclíková, Monika Bolek, Tomáš Staško, Ján Samoš, Matej Mokáň, Marián |
author_sort | Strýčková, Alena |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients. |
format | Online Article Text |
id | pubmed-9436625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94366252022-09-02 SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition Strýčková, Alena Benko, Jakub Péč, Martin Jozef Péčová, Monika Žolková, Jana Brunclíková, Monika Bolek, Tomáš Staško, Ján Samoš, Matej Mokáň, Marián Case Rep Hematol Case Report Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients. Hindawi 2022-08-25 /pmc/articles/PMC9436625/ /pubmed/36060118 http://dx.doi.org/10.1155/2022/7805900 Text en Copyright © 2022 Alena Strýčková et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Strýčková, Alena Benko, Jakub Péč, Martin Jozef Péčová, Monika Žolková, Jana Brunclíková, Monika Bolek, Tomáš Staško, Ján Samoš, Matej Mokáň, Marián SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
title | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
title_full | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
title_fullStr | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
title_full_unstemmed | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
title_short | SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition |
title_sort | sars-cov-2 infection-associated aortic thrombosis treated with oral factor xa inhibition |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436625/ https://www.ncbi.nlm.nih.gov/pubmed/36060118 http://dx.doi.org/10.1155/2022/7805900 |
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