Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease

Chronic kidney disease (CKD) is well recognized as a distinct contributor to cardiac hypertrophy, while the underlying mechanism remains incompletely understood. Here, the authors show that myocardial mitochondrial oxidative damage is early and prominent in CKD and distinctively stimulates the STING...

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Detalles Bibliográficos
Autores principales: Han, Wenhao, Du, Changhong, Zhu, Yingguo, Ran, Li, Wang, Yue, Xiong, Jiachuan, Wu, Yiding, Lan, Qigang, Wang, Yaqin, Wang, Liting, Wang, Junping, Yang, Ke, Zhao, Jinghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436763/
https://www.ncbi.nlm.nih.gov/pubmed/36061341
http://dx.doi.org/10.1016/j.jacbts.2022.03.006

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