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Optical control of the β(2)-adrenergic receptor with opto-prop-2: A cis-active azobenzene analog of propranolol

In this study, we synthesized and evaluated new photoswitchable ligands for the beta-adrenergic receptors β(1)-AR and β(2)-AR, applying an azologization strategy to the first-generation beta-blocker propranolol. The resulting compounds (Opto-prop-1, -2, -3) have good photochemical properties with hi...

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Detalles Bibliográficos
Autores principales:	Bosma, Reggie, Dijon, Nicola C., Zheng, Yang, Schihada, Hannes, Hauwert, Niels J., Shi, Shuang, Arimont, Marta, Riemens, Rick, Custers, Hans, van de Stolpe, Andrea, Vischer, Henry F., Wijtmans, Maikel, Holliday, Nicholas D., Kuster, Diederik W.D., Leurs, Rob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436767/ https://www.ncbi.nlm.nih.gov/pubmed/36060054 http://dx.doi.org/10.1016/j.isci.2022.104882

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