Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state

The intramembrane protease PARL acts as a crucial mitochondrial safeguard by cleaving the mitophagy regulators PINK1 and PGAM5. Depending on the stress level, PGAM5 can either stimulate cell survival or cell death. In contrast to PINK1, which is constantly cleaved in healthy mitochondria and only ac...

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Detalles Bibliográficos
Autores principales: Siebert, Verena, Silber, Mara, Heuten, Elena, Muhle-Goll, Claudia, Lemberg, Marius K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436811/
https://www.ncbi.nlm.nih.gov/pubmed/35921890
http://dx.doi.org/10.1016/j.jbc.2022.102321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436811/
https://www.ncbi.nlm.nih.gov/pubmed/35921890
http://dx.doi.org/10.1016/j.jbc.2022.102321

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