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Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress
Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaque...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436817/ https://www.ncbi.nlm.nih.gov/pubmed/36061342 http://dx.doi.org/10.1016/j.jacbts.2022.03.013 |
| _version_ | 1784781457401577472 |
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| author | Chen, Yihong Shen, Junyan Nilsson, Anna Hultgårdh Goncalves, Isabel Edsfeldt, Andreas Engström, Gunnar Zaigham, Suneela Melander, Olle Orho-Melander, Marju Rauch, Uwe Venuraju, Shreenidhi M. Lahiri, Avijit Liang, Chun Nilsson, Jan |
| author_facet | Chen, Yihong Shen, Junyan Nilsson, Anna Hultgårdh Goncalves, Isabel Edsfeldt, Andreas Engström, Gunnar Zaigham, Suneela Melander, Olle Orho-Melander, Marju Rauch, Uwe Venuraju, Shreenidhi M. Lahiri, Avijit Liang, Chun Nilsson, Jan |
| author_sort | Chen, Yihong |
| collection | PubMed |
| description | Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke. |
| format | Online Article Text |
| id | pubmed-9436817 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94368172022-09-03 Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress Chen, Yihong Shen, Junyan Nilsson, Anna Hultgårdh Goncalves, Isabel Edsfeldt, Andreas Engström, Gunnar Zaigham, Suneela Melander, Olle Orho-Melander, Marju Rauch, Uwe Venuraju, Shreenidhi M. Lahiri, Avijit Liang, Chun Nilsson, Jan JACC Basic Transl Sci Original Research - Clinical Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke. Elsevier 2022-07-20 /pmc/articles/PMC9436817/ /pubmed/36061342 http://dx.doi.org/10.1016/j.jacbts.2022.03.013 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Original Research - Clinical Chen, Yihong Shen, Junyan Nilsson, Anna Hultgårdh Goncalves, Isabel Edsfeldt, Andreas Engström, Gunnar Zaigham, Suneela Melander, Olle Orho-Melander, Marju Rauch, Uwe Venuraju, Shreenidhi M. Lahiri, Avijit Liang, Chun Nilsson, Jan Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress |
| title | Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress |
| title_full | Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress |
| title_fullStr | Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress |
| title_full_unstemmed | Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress |
| title_short | Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress |
| title_sort | circulating hepatocyte growth factor reflects activation of vascular repair in response to stress |
| topic | Original Research - Clinical |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436817/ https://www.ncbi.nlm.nih.gov/pubmed/36061342 http://dx.doi.org/10.1016/j.jacbts.2022.03.013 |
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