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Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca(2+) Overload

Mitochondrial Ca(2+) overload contributes to obesity cardiomyopathy, yet mechanisms that directly regulate it remain elusive. The authors investigated the role of Parkin on obesity-induced cardiac remodeling and dysfunction in human hearts and a mouse model of 24-week high-fat diet (HFD) feeding. Pa...

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Detalles Bibliográficos
Autores principales:	Wu, Ne N., Bi, Yaguang, Ajoolabady, Amir, You, Fei, Sowers, James, Wang, Qiurong, Ceylan, Asli F., Zhang, Yingmei, Ren, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research - Preclinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436824/ https://www.ncbi.nlm.nih.gov/pubmed/36061337 http://dx.doi.org/10.1016/j.jacbts.2022.03.007

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