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Phase II study of BKM120 in patients with advanced esophageal squamous cell carcinoma (EPOC1303)

BACKGROUND: PI3K/AKT/mTOR pathway is frequently overactive in esophageal squamous cell carcinoma (ESCC), making it an attractive treatment target. BKM120 is an oral pan-class I PI3K inhibitor with promising activity in several cancers. We prospectively investigated efficacy, safety, and biomarkers o...

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Detalles Bibliográficos
Autores principales:	Kojima, Takashi, Kato, Ken, Hara, Hiroki, Takahashi, Shunji, Muro, Kei, Nishina, Tomohiro, Wakabayashi, Masashi, Nomura, Shogo, Sato, Akihiro, Ohtsu, Atsushi, Doi, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436835/ https://www.ncbi.nlm.nih.gov/pubmed/35904643 http://dx.doi.org/10.1007/s10388-022-00928-3

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