GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL

NOTCH1 alterations have been associated with chronic lymphocytic leukemia (CLL), but the molecular mechanisms underlying NOTCH1 activation in CLL cells are not completely understood. Here, we show that GSK3β downregulates the constitutive levels of the active NOTCH1 intracellular domain (N1-ICD) in...

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Detalles Bibliográficos
Autores principales: De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Esposito, Angela, Scialdone, Annarita, Baldoni, Stefano, Del Papa, Beatrice, Adamo, Francesco Maria, Silva Barcelos, Estevão Carlos, Dorillo, Erica, Stella, Arianna, Di Ianni, Mauro, Screpanti, Isabella, Sportoletti, Paolo, Rosati, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436923/
https://www.ncbi.nlm.nih.gov/pubmed/36050315
http://dx.doi.org/10.1038/s41419-022-05178-w

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