Heterogeneity and transcriptome changes of human CD8(+) T cells across nine decades of life

The decline of CD8(+) T cell functions contributes to deteriorating health with aging, but the mechanisms that underlie this phenomenon are not well understood. We use single-cell RNA sequencing with both cross-sectional and longitudinal samples to assess how human CD8(+) T cell heterogeneity and tr...

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Detalles Bibliográficos
Autores principales: Lu, Jian, Ahmad, Raheel, Nguyen, Thomas, Cifello, Jeffrey, Hemani, Humza, Li, Jiangyuan, Chen, Jinguo, Li, Siyi, Wang, Jing, Achour, Achouak, Chen, Joseph, Colie, Meagan, Lustig, Ana, Dunn, Christopher, Zukley, Linda, Chia, Chee W., Burd, Irina, Zhu, Jun, Ferrucci, Luigi, Weng, Nan-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436929/
https://www.ncbi.nlm.nih.gov/pubmed/36050300
http://dx.doi.org/10.1038/s41467-022-32869-x

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