Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin

DNA end resection is delicately regulated through various types of post-translational modifications to initiate homologous recombination, but the involvement of SUMOylation in this process remains incompletely understood. Here, we show that MRE11 requires SUMOylation to shield it from ubiquitin-medi...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Yang, Han, Zhou, Zenan, Bai, Yongtai, Wang, Jiadong, Wang, Weibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436968/
https://www.ncbi.nlm.nih.gov/pubmed/36050397
http://dx.doi.org/10.1038/s41467-022-32920-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436968/
https://www.ncbi.nlm.nih.gov/pubmed/36050397
http://dx.doi.org/10.1038/s41467-022-32920-x

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