Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)

Sizzled (Szl) is both a secreted frizzled related protein (sFRP) and a naturally occurring inhibitor of the zinc metalloproteinase bone morphogenetic protein-1 (BMP-1), a key regulator of extracellular matrix assembly and growth factor activation. Here we present a new crystal structure for Szl whic...

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Detalles Bibliográficos
Autores principales: Sharma, Urvashi, Vadon-Le Goff, Sandrine, Harlos, Karl, Zhao, Yuguang, Mariano, Natacha, Bijakowski, Cecile, Bourhis, Jean-Marie, Moali, Catherine, Hulmes, David J. S., Aghajari, Nushin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437010/
https://www.ncbi.nlm.nih.gov/pubmed/36050373
http://dx.doi.org/10.1038/s41598-022-18795-4

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