Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans. However, residual mouse hepatocytes occasionally prevent the precise evaluation of human drug metabolism. Herein, we developed a novel humanized liver TK-NOG mouse with a...

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Detalles Bibliográficos
Autores principales: Uehara, Shotaro, Iida, Yuichi, Ida-Tanaka, Miyuki, Goto, Motohito, Kawai, Kenji, Yamamoto, Masafumi, Higuchi, Yuichiro, Ito, Satoshi, Takahashi, Riichi, Kamimura, Hidetaka, Ito, Mamoru, Yamazaki, Hiroshi, Oshimura, Mitsuo, Kazuki, Yasuhiro, Suemizu, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437039/
https://www.ncbi.nlm.nih.gov/pubmed/36050438
http://dx.doi.org/10.1038/s41598-022-19242-0

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