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PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer

The upregulated proline rich 11 (PRR11) plays a critical role in cancer progression. The relevant biological functions of PRR11 in pan-cancer development are not well understood. In the current study, we found that PRR11 was upregulated in 19 cancer types compared with that of normal tissues and hig...

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Autores principales: Zhang, Haibo, He, Ziqing, Qiu, Li, Wei, Jinfen, Gong, Xiaocheng, Xian, Mingjian, Chen, Zixi, Cui, Ying, Fu, Shuying, Zhang, Zihao, Hu, Bowen, Zhang, Xiquan, Lin, Shudai, Du, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437250/
https://www.ncbi.nlm.nih.gov/pubmed/36060253
http://dx.doi.org/10.3389/fmolb.2022.877320
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author Zhang, Haibo
He, Ziqing
Qiu, Li
Wei, Jinfen
Gong, Xiaocheng
Xian, Mingjian
Chen, Zixi
Cui, Ying
Fu, Shuying
Zhang, Zihao
Hu, Bowen
Zhang, Xiquan
Lin, Shudai
Du, Hongli
author_facet Zhang, Haibo
He, Ziqing
Qiu, Li
Wei, Jinfen
Gong, Xiaocheng
Xian, Mingjian
Chen, Zixi
Cui, Ying
Fu, Shuying
Zhang, Zihao
Hu, Bowen
Zhang, Xiquan
Lin, Shudai
Du, Hongli
author_sort Zhang, Haibo
collection PubMed
description The upregulated proline rich 11 (PRR11) plays a critical role in cancer progression. The relevant biological functions of PRR11 in pan-cancer development are not well understood. In the current study, we found that PRR11 was upregulated in 19 cancer types compared with that of normal tissues and high-expressed PRR11 was a predictor of poor prognosis in 10 cancer types by bioinformatics. Then we showed that interfering PRR11 on three cancer cell lines could greatly inhibit cell proliferation and migration and arrest cells to S phase in vivo. Based on RNA-seq, downregulation of PRR11 expression could extremely suppress the expression of PTTG1 and the cell cycle pathway identified by a differentially expressed gene analysis and an enrichment analysis. The expression of PRR11 and PTTG1 was positively correlated in TCGA and independent GEO data sets. Importantly, we revealed that the PRR11 could express itself in the nucleus and interact with E2F1 on the PTTG1 promoter region to increase the expression of PTTG1. Further results indicated that the expression of PTTG1 was also associated with poor prognosis in 10 cancer types, while downregulation of PTTG1 expression could inhibit cancer cell proliferation and migration. Therefore, we found that PRR11 served as an oncogene in pan-cancer and could influence the cell cycle progression through regulating the expression of PTTG1 by interacting with the transcription factor E2F1.
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spelling pubmed-94372502022-09-03 PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer Zhang, Haibo He, Ziqing Qiu, Li Wei, Jinfen Gong, Xiaocheng Xian, Mingjian Chen, Zixi Cui, Ying Fu, Shuying Zhang, Zihao Hu, Bowen Zhang, Xiquan Lin, Shudai Du, Hongli Front Mol Biosci Molecular Biosciences The upregulated proline rich 11 (PRR11) plays a critical role in cancer progression. The relevant biological functions of PRR11 in pan-cancer development are not well understood. In the current study, we found that PRR11 was upregulated in 19 cancer types compared with that of normal tissues and high-expressed PRR11 was a predictor of poor prognosis in 10 cancer types by bioinformatics. Then we showed that interfering PRR11 on three cancer cell lines could greatly inhibit cell proliferation and migration and arrest cells to S phase in vivo. Based on RNA-seq, downregulation of PRR11 expression could extremely suppress the expression of PTTG1 and the cell cycle pathway identified by a differentially expressed gene analysis and an enrichment analysis. The expression of PRR11 and PTTG1 was positively correlated in TCGA and independent GEO data sets. Importantly, we revealed that the PRR11 could express itself in the nucleus and interact with E2F1 on the PTTG1 promoter region to increase the expression of PTTG1. Further results indicated that the expression of PTTG1 was also associated with poor prognosis in 10 cancer types, while downregulation of PTTG1 expression could inhibit cancer cell proliferation and migration. Therefore, we found that PRR11 served as an oncogene in pan-cancer and could influence the cell cycle progression through regulating the expression of PTTG1 by interacting with the transcription factor E2F1. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9437250/ /pubmed/36060253 http://dx.doi.org/10.3389/fmolb.2022.877320 Text en Copyright © 2022 Zhang, He, Qiu, Wei, Gong, Xian, Chen, Cui, Fu, Zhang, Hu, Zhang, Lin and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Zhang, Haibo
He, Ziqing
Qiu, Li
Wei, Jinfen
Gong, Xiaocheng
Xian, Mingjian
Chen, Zixi
Cui, Ying
Fu, Shuying
Zhang, Zihao
Hu, Bowen
Zhang, Xiquan
Lin, Shudai
Du, Hongli
PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer
title PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer
title_full PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer
title_fullStr PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer
title_full_unstemmed PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer
title_short PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer
title_sort prr11 promotes cell proliferation by regulating pttg1 through interacting with e2f1 transcription factor in pan-cancer
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437250/
https://www.ncbi.nlm.nih.gov/pubmed/36060253
http://dx.doi.org/10.3389/fmolb.2022.877320
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