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Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report
Leukocyte chemotactic factor 2-associated (ALECT2) amyloidosis is one of the recently reported types of amyloidosis, which is caused by the extracellular deposition of leukocyte chemotactic factor 2 (LECT2). There have not been any reports involving the concurrence of ALECT2 amyloidosis with Sjögren...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437290/ https://www.ncbi.nlm.nih.gov/pubmed/36059556 http://dx.doi.org/10.3389/fimmu.2022.966591 |
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author | Wang, Shuang Yu, Xiao-juan Li, Dan-yang Xu, Jin Wang, Su-xia |
author_facet | Wang, Shuang Yu, Xiao-juan Li, Dan-yang Xu, Jin Wang, Su-xia |
author_sort | Wang, Shuang |
collection | PubMed |
description | Leukocyte chemotactic factor 2-associated (ALECT2) amyloidosis is one of the recently reported types of amyloidosis, which is caused by the extracellular deposition of leukocyte chemotactic factor 2 (LECT2). There have not been any reports involving the concurrence of ALECT2 amyloidosis with Sjögren’s syndrome (SS) or systemic lupus erythematosus (SLE)s. Herein, we report a case of a 68-year-old Chinese woman presenting with long duration of sicca symptoms. The clinical evaluation and laboratory findings showed that she had SS overlapped with SLE. Kidney biopsy revealed a membranoproliferative glomerulonephritis (MPGN) with glomerular deposition of dominant IgG3-kappa by immunofluorescene, which was related to SS/SLE. Furthermore, patchy congophilic amyloid deposits in the tubulointerstitium were detected, which were positive for LECT2 protein by immunohistochemical staining and immunoelectron microscopy. This is the first case of ALECT2 amyloidosis that coexisted with SS/SLE, and the causal relationship between ALECT2 amyloidosis and autoimmune diseases remain unclear. |
format | Online Article Text |
id | pubmed-9437290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94372902022-09-03 Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report Wang, Shuang Yu, Xiao-juan Li, Dan-yang Xu, Jin Wang, Su-xia Front Immunol Immunology Leukocyte chemotactic factor 2-associated (ALECT2) amyloidosis is one of the recently reported types of amyloidosis, which is caused by the extracellular deposition of leukocyte chemotactic factor 2 (LECT2). There have not been any reports involving the concurrence of ALECT2 amyloidosis with Sjögren’s syndrome (SS) or systemic lupus erythematosus (SLE)s. Herein, we report a case of a 68-year-old Chinese woman presenting with long duration of sicca symptoms. The clinical evaluation and laboratory findings showed that she had SS overlapped with SLE. Kidney biopsy revealed a membranoproliferative glomerulonephritis (MPGN) with glomerular deposition of dominant IgG3-kappa by immunofluorescene, which was related to SS/SLE. Furthermore, patchy congophilic amyloid deposits in the tubulointerstitium were detected, which were positive for LECT2 protein by immunohistochemical staining and immunoelectron microscopy. This is the first case of ALECT2 amyloidosis that coexisted with SS/SLE, and the causal relationship between ALECT2 amyloidosis and autoimmune diseases remain unclear. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9437290/ /pubmed/36059556 http://dx.doi.org/10.3389/fimmu.2022.966591 Text en Copyright © 2022 Wang, Yu, Li, Xu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wang, Shuang Yu, Xiao-juan Li, Dan-yang Xu, Jin Wang, Su-xia Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report |
title | Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report |
title_full | Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report |
title_fullStr | Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report |
title_full_unstemmed | Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report |
title_short | Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report |
title_sort | concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: a case report |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437290/ https://www.ncbi.nlm.nih.gov/pubmed/36059556 http://dx.doi.org/10.3389/fimmu.2022.966591 |
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