Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report

BACKGROUND: Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessel vasculitis, typical of childhood. It’s a self-limiting disease and it affects different systems. HSP is characterized by dermatological, abdominal, joint and renal clinical manifestations. This condition usually occurs upon i...

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Autores principales: Casini, Francesca, Magenes, Vittoria Carlotta, De Sanctis, Marina, Gattinara, Maurizio, Pandolfi, Marco, Cambiaghi, Stefano, Zuccotti, Gian Vincenzo, Fabiano, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437414/
https://www.ncbi.nlm.nih.gov/pubmed/36056360
http://dx.doi.org/10.1186/s13052-022-01351-1
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author Casini, Francesca
Magenes, Vittoria Carlotta
De Sanctis, Marina
Gattinara, Maurizio
Pandolfi, Marco
Cambiaghi, Stefano
Zuccotti, Gian Vincenzo
Fabiano, Valentina
author_facet Casini, Francesca
Magenes, Vittoria Carlotta
De Sanctis, Marina
Gattinara, Maurizio
Pandolfi, Marco
Cambiaghi, Stefano
Zuccotti, Gian Vincenzo
Fabiano, Valentina
author_sort Casini, Francesca
collection PubMed
description BACKGROUND: Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessel vasculitis, typical of childhood. It’s a self-limiting disease and it affects different systems. HSP is characterized by dermatological, abdominal, joint and renal clinical manifestations. This condition usually occurs upon infections, mainly upper respiratory tract ones, medications, vaccinations and malignancies. CASE PRESENTATION: We describe the case of a 11 year-old girl who developed a urticarial rash 12 days after the first dose of Pfizer-BioNTech BNT16B2b2 mRNA vaccine and a clear picture of Henoch Schönlein purpura 5 days after administration of the second dose of the same vaccine. CONCLUSION: To our knowledge, this is the first description of a pediatric patient with Henoch-Schönlein purpura occurring in association with vaccination against COVID-19.
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spelling pubmed-94374142022-09-02 Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report Casini, Francesca Magenes, Vittoria Carlotta De Sanctis, Marina Gattinara, Maurizio Pandolfi, Marco Cambiaghi, Stefano Zuccotti, Gian Vincenzo Fabiano, Valentina Ital J Pediatr Case Report BACKGROUND: Henoch-Schönlein purpura (HSP) is an IgA-mediated small vessel vasculitis, typical of childhood. It’s a self-limiting disease and it affects different systems. HSP is characterized by dermatological, abdominal, joint and renal clinical manifestations. This condition usually occurs upon infections, mainly upper respiratory tract ones, medications, vaccinations and malignancies. CASE PRESENTATION: We describe the case of a 11 year-old girl who developed a urticarial rash 12 days after the first dose of Pfizer-BioNTech BNT16B2b2 mRNA vaccine and a clear picture of Henoch Schönlein purpura 5 days after administration of the second dose of the same vaccine. CONCLUSION: To our knowledge, this is the first description of a pediatric patient with Henoch-Schönlein purpura occurring in association with vaccination against COVID-19. BioMed Central 2022-09-02 /pmc/articles/PMC9437414/ /pubmed/36056360 http://dx.doi.org/10.1186/s13052-022-01351-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Casini, Francesca
Magenes, Vittoria Carlotta
De Sanctis, Marina
Gattinara, Maurizio
Pandolfi, Marco
Cambiaghi, Stefano
Zuccotti, Gian Vincenzo
Fabiano, Valentina
Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report
title Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report
title_full Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report
title_fullStr Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report
title_full_unstemmed Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report
title_short Henoch-Schönlein purpura following COVID-19 vaccine in a child: a case report
title_sort henoch-schönlein purpura following covid-19 vaccine in a child: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437414/
https://www.ncbi.nlm.nih.gov/pubmed/36056360
http://dx.doi.org/10.1186/s13052-022-01351-1
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