Cargando…
Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection
INTRODUCTION: Stress hyperglycemia is a frequent finding in patients with COVID-19 infection and could affect the outcome of disease. Cytokines released in response to infection could have adverse effects on insulin sensitivity and pancreatic beta-cell function. The aim of the study was to examine t...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437426/ https://www.ncbi.nlm.nih.gov/pubmed/36059840 http://dx.doi.org/10.3389/fmed.2022.988686 |
_version_ | 1784781608175271936 |
---|---|
author | Da Porto, Andrea Tascini, Carlo Colussi, Gianluca Peghin, Maddalena Graziano, Elena De Carlo, Chiara Bulfone, Luca Antonello, Martina Sozio, Emanuela Fabris, Martina Curcio, Francesco Pucillo, Carlo Catena, Cristiana Sechi, Leonardo A. |
author_facet | Da Porto, Andrea Tascini, Carlo Colussi, Gianluca Peghin, Maddalena Graziano, Elena De Carlo, Chiara Bulfone, Luca Antonello, Martina Sozio, Emanuela Fabris, Martina Curcio, Francesco Pucillo, Carlo Catena, Cristiana Sechi, Leonardo A. |
author_sort | Da Porto, Andrea |
collection | PubMed |
description | INTRODUCTION: Stress hyperglycemia is a frequent finding in patients with COVID-19 infection and could affect the outcome of disease. Cytokines released in response to infection could have adverse effects on insulin sensitivity and pancreatic beta-cell function. The aim of the study was to examine the relationships of stress hyperglycemia with cytokines and clinical outcomes in hospitalized patients with COVID-19. METHODS: In a cross-sectional analysis of 150 patients hospitalized for COVID-19 infection who were included in the GIRA-COVID database, we identified patients with stress hyperglycemia by calculation of the Stress Hyperglycemia Ratio (SHR) and use of a cut-off of 1.14. Plasma levels of cytokines principally involved in COVID-19 infection-related cytokine storm were measured. Outcome variables were use of mechanical ventilation and death within 60 days from hospital admission. RESULTS: Patients with SHR > 1.14 had significantly higher plasma insulin, HOMA-index, and levels of interleukin-10 (IL-10), interleukin-10/tumor necrosis factor-a ratio (IL-10/TNF-α), and CXC motif chemokine ligand 10 (CXCL10) than patients with SHR ≤ 1.14. IL-10, IL-10/TNF-α ratio, CXCL10, and IFN-γ were significantly and directly related with SHR in univariate analysis and multivariate logistic regression models showed that IL-10, IL-10/TNF-α ratio, and CXCL10 were independently associated with SHR>1.14. In a multivariate logistic model, stress hyperglycemia predicted use of mechanical ventilation (OR 2.453; CI 1.078–6.012) and death (OR 2.281; CI 1.049–7.369) independently of diabetes and other major confounders. CONCLUSIONS: In patients hospitalized for COVID-19 infection, stress hyperglycemia is associated with worse clinical outcomes and is independently related to levels of cytokines that might impair glucose homeostasis. |
format | Online Article Text |
id | pubmed-9437426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94374262022-09-03 Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection Da Porto, Andrea Tascini, Carlo Colussi, Gianluca Peghin, Maddalena Graziano, Elena De Carlo, Chiara Bulfone, Luca Antonello, Martina Sozio, Emanuela Fabris, Martina Curcio, Francesco Pucillo, Carlo Catena, Cristiana Sechi, Leonardo A. Front Med (Lausanne) Medicine INTRODUCTION: Stress hyperglycemia is a frequent finding in patients with COVID-19 infection and could affect the outcome of disease. Cytokines released in response to infection could have adverse effects on insulin sensitivity and pancreatic beta-cell function. The aim of the study was to examine the relationships of stress hyperglycemia with cytokines and clinical outcomes in hospitalized patients with COVID-19. METHODS: In a cross-sectional analysis of 150 patients hospitalized for COVID-19 infection who were included in the GIRA-COVID database, we identified patients with stress hyperglycemia by calculation of the Stress Hyperglycemia Ratio (SHR) and use of a cut-off of 1.14. Plasma levels of cytokines principally involved in COVID-19 infection-related cytokine storm were measured. Outcome variables were use of mechanical ventilation and death within 60 days from hospital admission. RESULTS: Patients with SHR > 1.14 had significantly higher plasma insulin, HOMA-index, and levels of interleukin-10 (IL-10), interleukin-10/tumor necrosis factor-a ratio (IL-10/TNF-α), and CXC motif chemokine ligand 10 (CXCL10) than patients with SHR ≤ 1.14. IL-10, IL-10/TNF-α ratio, CXCL10, and IFN-γ were significantly and directly related with SHR in univariate analysis and multivariate logistic regression models showed that IL-10, IL-10/TNF-α ratio, and CXCL10 were independently associated with SHR>1.14. In a multivariate logistic model, stress hyperglycemia predicted use of mechanical ventilation (OR 2.453; CI 1.078–6.012) and death (OR 2.281; CI 1.049–7.369) independently of diabetes and other major confounders. CONCLUSIONS: In patients hospitalized for COVID-19 infection, stress hyperglycemia is associated with worse clinical outcomes and is independently related to levels of cytokines that might impair glucose homeostasis. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9437426/ /pubmed/36059840 http://dx.doi.org/10.3389/fmed.2022.988686 Text en Copyright © 2022 Da Porto, Tascini, Colussi, Peghin, Graziano, De Carlo, Bulfone, Antonello, Sozio, Fabris, Curcio, Pucillo, Catena and Sechi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Da Porto, Andrea Tascini, Carlo Colussi, Gianluca Peghin, Maddalena Graziano, Elena De Carlo, Chiara Bulfone, Luca Antonello, Martina Sozio, Emanuela Fabris, Martina Curcio, Francesco Pucillo, Carlo Catena, Cristiana Sechi, Leonardo A. Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection |
title | Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection |
title_full | Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection |
title_fullStr | Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection |
title_full_unstemmed | Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection |
title_short | Relationship between cytokine release and stress hyperglycemia in patients hospitalized with COVID-19 infection |
title_sort | relationship between cytokine release and stress hyperglycemia in patients hospitalized with covid-19 infection |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437426/ https://www.ncbi.nlm.nih.gov/pubmed/36059840 http://dx.doi.org/10.3389/fmed.2022.988686 |
work_keys_str_mv | AT daportoandrea relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT tascinicarlo relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT colussigianluca relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT peghinmaddalena relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT grazianoelena relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT decarlochiara relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT bulfoneluca relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT antonellomartina relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT sozioemanuela relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT fabrismartina relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT curciofrancesco relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT pucillocarlo relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT catenacristiana relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection AT sechileonardoa relationshipbetweencytokinereleaseandstresshyperglycemiainpatientshospitalizedwithcovid19infection |