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Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes

Cognitive impairment is highly prevalent in patients with major psychiatric disorders (MPDs), including schizophrenia (SCZ), bipolar disorder, major depressive disorder, in whom it can be highly disruptive to community functioning and worsen prognosis. Previously, genetic factors and cognitive impai...

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Autores principales: Zhuo, Chuanjun, Tian, Hongjun, Chen, Jiayue, Li, Qianchen, Yang, Lei, Zhang, Qiuyu, Chen, Guangdong, Cheng, Langlang, Zhou, Chunhua, Song, Xueqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437456/
https://www.ncbi.nlm.nih.gov/pubmed/36061201
http://dx.doi.org/10.3389/fgene.2022.880027
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author Zhuo, Chuanjun
Tian, Hongjun
Chen, Jiayue
Li, Qianchen
Yang, Lei
Zhang, Qiuyu
Chen, Guangdong
Cheng, Langlang
Zhou, Chunhua
Song, Xueqin
author_facet Zhuo, Chuanjun
Tian, Hongjun
Chen, Jiayue
Li, Qianchen
Yang, Lei
Zhang, Qiuyu
Chen, Guangdong
Cheng, Langlang
Zhou, Chunhua
Song, Xueqin
author_sort Zhuo, Chuanjun
collection PubMed
description Cognitive impairment is highly prevalent in patients with major psychiatric disorders (MPDs), including schizophrenia (SCZ), bipolar disorder, major depressive disorder, in whom it can be highly disruptive to community functioning and worsen prognosis. Previously, genetic factors and cognitive impairments in MPD patients have been examined mostly in isolated circuits rather than in the whole brain. In the present study, genetic, neuroimaging, and psychometric approaches were combined to investigate the relationship among genetic factors, alterations throughout the brain, and cognitive impairments in a large cohort of patients diagnosed with SCZ, with a reference healthy control (HC) group. Single nucleotide polymorphisms (SNPs) in SCZ-risk genes were found to be strongly related to cognitive impairments as well as to gray matter volume (GMV) and functional connectivity (FC) alterations in the SCZ group. Annotating 136 high-ranking SNPs revealed 65 affected genes (including PPP1R16B, GBBR2, PDE4B, CANCNA1C, SLC12AB, SATB2, MAG12, and SATB2). Only one, a PDE4B SNP (rs1006737), correlated with GMV (r = 0:19 p = 0.015) and FC (r = 0.21, p = 0.0074) in SCZ patients. GMV and FC alterations correlated with one another broadly across brain regions. Moreover, the present data demonstrate three-way SNP-FC-GMV associations in patients with SCZ, thus providing clues regarding potential genetic bases of cognition impairments in SCZ. SNP-FC-GMV relationships correlated with visual learning and reasoning dimensions of cognition. These data provide evidence that SCZ-related cognitive impairments may reflect genetically underlain whole-brain structural and functional alterations.
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spelling pubmed-94374562022-09-03 Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes Zhuo, Chuanjun Tian, Hongjun Chen, Jiayue Li, Qianchen Yang, Lei Zhang, Qiuyu Chen, Guangdong Cheng, Langlang Zhou, Chunhua Song, Xueqin Front Genet Genetics Cognitive impairment is highly prevalent in patients with major psychiatric disorders (MPDs), including schizophrenia (SCZ), bipolar disorder, major depressive disorder, in whom it can be highly disruptive to community functioning and worsen prognosis. Previously, genetic factors and cognitive impairments in MPD patients have been examined mostly in isolated circuits rather than in the whole brain. In the present study, genetic, neuroimaging, and psychometric approaches were combined to investigate the relationship among genetic factors, alterations throughout the brain, and cognitive impairments in a large cohort of patients diagnosed with SCZ, with a reference healthy control (HC) group. Single nucleotide polymorphisms (SNPs) in SCZ-risk genes were found to be strongly related to cognitive impairments as well as to gray matter volume (GMV) and functional connectivity (FC) alterations in the SCZ group. Annotating 136 high-ranking SNPs revealed 65 affected genes (including PPP1R16B, GBBR2, PDE4B, CANCNA1C, SLC12AB, SATB2, MAG12, and SATB2). Only one, a PDE4B SNP (rs1006737), correlated with GMV (r = 0:19 p = 0.015) and FC (r = 0.21, p = 0.0074) in SCZ patients. GMV and FC alterations correlated with one another broadly across brain regions. Moreover, the present data demonstrate three-way SNP-FC-GMV associations in patients with SCZ, thus providing clues regarding potential genetic bases of cognition impairments in SCZ. SNP-FC-GMV relationships correlated with visual learning and reasoning dimensions of cognition. These data provide evidence that SCZ-related cognitive impairments may reflect genetically underlain whole-brain structural and functional alterations. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9437456/ /pubmed/36061201 http://dx.doi.org/10.3389/fgene.2022.880027 Text en Copyright © 2022 Zhuo, Tian, Chen, Li, Yang, Zhang, Chen, Cheng, Zhou and Song. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhuo, Chuanjun
Tian, Hongjun
Chen, Jiayue
Li, Qianchen
Yang, Lei
Zhang, Qiuyu
Chen, Guangdong
Cheng, Langlang
Zhou, Chunhua
Song, Xueqin
Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
title Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
title_full Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
title_fullStr Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
title_full_unstemmed Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
title_short Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
title_sort associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437456/
https://www.ncbi.nlm.nih.gov/pubmed/36061201
http://dx.doi.org/10.3389/fgene.2022.880027
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