Postponement of the opacification of lentoid bodies derived from human induced pluripotent stem cells after lanosterol treatment—the first use of the lens aging model in vitro in cataract drug screening

Purpose: Our previous study observed that human induced pluripotent stem cell (HiPSC)-derived lentoid bodies (LBs) became cloudy with extended culture time, partially mimicking the progress of human age-related cataracts (ARCs) in a dish. In the present study, lanosterol, a potential anticataract dr...

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Detalles Bibliográficos
Autores principales: Zhang, Lifang, Qin, Zhenwei, Lyu, Danni, Lu, Bing, Chen, Zhijian, Fu, Qiuli, Yao, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437520/
https://www.ncbi.nlm.nih.gov/pubmed/36059984
http://dx.doi.org/10.3389/fphar.2022.959978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437520/
https://www.ncbi.nlm.nih.gov/pubmed/36059984
http://dx.doi.org/10.3389/fphar.2022.959978

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