Neutrophil extracellular traps: New players in cancer research

NETs are chromatin-derived webs extruded from neutrophils as a result of either infection or sterile stimulation using chemicals, cytokines, or microbes. In addition to the classical role that NETs play in innate immunity against infection and injuries, NETs have been implicated extensively in cance...

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Detalles Bibliográficos
Autores principales: Zhao, Junjie, Jin, Jiaqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437524/
https://www.ncbi.nlm.nih.gov/pubmed/36059520
http://dx.doi.org/10.3389/fimmu.2022.937565
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author Zhao, Junjie
Jin, Jiaqi
author_facet Zhao, Junjie
Jin, Jiaqi
author_sort Zhao, Junjie
collection PubMed
description NETs are chromatin-derived webs extruded from neutrophils as a result of either infection or sterile stimulation using chemicals, cytokines, or microbes. In addition to the classical role that NETs play in innate immunity against infection and injuries, NETs have been implicated extensively in cancer progression, metastatic dissemination, and therapy resistance. The purpose of this review is to describe recent investigations into NETs and the roles they play in tumor biology and to explore their potential as therapeutic targets in cancer treatment.
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spelling pubmed-94375242022-09-03 Neutrophil extracellular traps: New players in cancer research Zhao, Junjie Jin, Jiaqi Front Immunol Immunology NETs are chromatin-derived webs extruded from neutrophils as a result of either infection or sterile stimulation using chemicals, cytokines, or microbes. In addition to the classical role that NETs play in innate immunity against infection and injuries, NETs have been implicated extensively in cancer progression, metastatic dissemination, and therapy resistance. The purpose of this review is to describe recent investigations into NETs and the roles they play in tumor biology and to explore their potential as therapeutic targets in cancer treatment. Frontiers Media S.A. 2022-08-19 /pmc/articles/PMC9437524/ /pubmed/36059520 http://dx.doi.org/10.3389/fimmu.2022.937565 Text en Copyright © 2022 Zhao and Jin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Junjie
Jin, Jiaqi
Neutrophil extracellular traps: New players in cancer research
title Neutrophil extracellular traps: New players in cancer research
title_full Neutrophil extracellular traps: New players in cancer research
title_fullStr Neutrophil extracellular traps: New players in cancer research
title_full_unstemmed Neutrophil extracellular traps: New players in cancer research
title_short Neutrophil extracellular traps: New players in cancer research
title_sort neutrophil extracellular traps: new players in cancer research
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437524/
https://www.ncbi.nlm.nih.gov/pubmed/36059520
http://dx.doi.org/10.3389/fimmu.2022.937565
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