SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivity to alkylation-based chemotherapy. RNF113A methyl...

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Detalles Bibliográficos
Autores principales: Lukinović, Valentina, Hausmann, Simone, Roth, Gael S., Oyeniran, Clement, Ahmad, Tanveer, Tsao, Ning, Brickner, Joshua R., Casanova, Alexandre G., Chuffart, Florent, Benitez, Ana Morales, Vayr, Jessica, Rodell, Rebecca, Tardif, Marianne, Jansen, Pascal W.T.C., Couté, Yohann, Vermeulen, Michiel, Hainaut, Pierre, Mazur, Pawel K., Mosammaparast, Nima, Reynoird, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437563/
https://www.ncbi.nlm.nih.gov/pubmed/35819319
http://dx.doi.org/10.1158/2159-8290.CD-21-0205

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