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PPM1D in Solid and Hematologic Malignancies: Friend and Foe?
In the face of constant genomic insults, the DNA damage response (DDR) is initiated to preserve genome integrity; its disruption is a classic hallmark of cancer. Protein phosphatase Mg(2+)/Mn(2+)–dependent 1D (PPM1D) is a central negative regulator of the DDR that is mutated or amplified in many sol...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Association for Cancer Research
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437564/ https://www.ncbi.nlm.nih.gov/pubmed/35657598 http://dx.doi.org/10.1158/1541-7786.MCR-21-1018 |