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Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages

Current chimeric antigen receptor-modified (CAR) T-cell products are evaluated in bulk, without assessing functional heterogeneity. We therefore generated a comprehensive single-cell gene expression and T-cell receptor (TCR) sequencing data set using pre- and postinfusion CD19-CAR T cells from blood...

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Detalles Bibliográficos
Autores principales:	Wilson, Taylor L., Kim, Hyunjin, Chou, Ching-Heng, Langfitt, Deanna, Mettelman, Robert C., Minervina, Anastasia A., Allen, E. Kaitlynn, Métais, Jean-Yves, Pogorelyy, Mikhail V., Riberdy, Janice M., Velasquez, M. Paulina, Kottapalli, Pratibha, Trivedi, Sanchit, Olsen, Scott R., Lockey, Timothy, Willis, Catherine, Meagher, Michael M., Triplett, Brandon M., Talleur, Aimee C., Gottschalk, Stephen, Crawford, Jeremy Chase, Thomas, Paul G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437573/ https://www.ncbi.nlm.nih.gov/pubmed/35792801 http://dx.doi.org/10.1158/2159-8290.CD-21-1508

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