FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Forkhead box R2 (FOXR2) is a forkhead transcription factor located on the X chromosome whose expression is normally restricted to the testis. In this study, we performed a pan-cancer analysis of FOXR2 activation across more than 10,000 adult and pediatric cancer samples and found FOXR2 to be aberran...

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Detalles Bibliográficos
Autores principales: Tsai, Jessica W., Cejas, Paloma, Wang, Dayle K., Patel, Smruti, Wu, David W., Arounleut, Phonepasong, Wei, Xin, Zhou, Ningxuan, Syamala, Sudeepa, Dubois, Frank P.B., Crane, Alexander, Pelton, Kristine, Vogelzang, Jayne, Sousa, Cecilia, Baguette, Audrey, Chen, Xiaolong, Condurat, Alexandra L., Dixon-Clarke, Sarah E., Zhou, Kevin N., Lu, Sophie D., Gonzalez, Elizabeth M., Chacon, Madison S., Digiacomo, Jeromy J., Kumbhani, Rushil, Novikov, Dana, Hunter, J'Ya, Tsoli, Maria, Ziegler, David S., Dirksen, Uta, Jager, Natalie, Balasubramanian, Gnana Prakash, Kramm, Christof M., Nathrath, Michaela, Bielack, Stefan, Baker, Suzanne J., Zhang, Jinghui, McFarland, James M., Getz, Gad, Aguet, François, Jabado, Nada, Witt, Olaf, Pfister, Stefan M., Ligon, Keith L., Hovestadt, Volker, Kleinman, Claudia L., Long, Henry, Jones, David T.W., Bandopadhayay, Pratiti, Phoenix, Timothy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Genome and Epigenome
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437574/
https://www.ncbi.nlm.nih.gov/pubmed/35802025
http://dx.doi.org/10.1158/0008-5472.CAN-22-0671

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