The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer

• The structure of glycoprotein Gc, responsible for membrane fusion, is revealed, but many more mysteries remain. • Why do only antibodies against Gc have neutralizing effect, but not the one against Gn? • Why can NAbs against Gc only be protective in the animals in preventive settings, but not in t...

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Detalles Bibliográficos
Autores principales: Ye, Wei, Ye, Chuantao, Hu, Yongliang, Dong, Yangchao, Lei, Yingfeng, Zhang, Fanglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437602/
https://www.ncbi.nlm.nih.gov/pubmed/35577043
http://dx.doi.org/10.1016/j.virs.2022.05.003
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author Ye, Wei
Ye, Chuantao
Hu, Yongliang
Dong, Yangchao
Lei, Yingfeng
Zhang, Fanglin
author_facet Ye, Wei
Ye, Chuantao
Hu, Yongliang
Dong, Yangchao
Lei, Yingfeng
Zhang, Fanglin
author_sort Ye, Wei
collection PubMed
description • The structure of glycoprotein Gc, responsible for membrane fusion, is revealed, but many more mysteries remain. • Why do only antibodies against Gc have neutralizing effect, but not the one against Gn? • Why can NAbs against Gc only be protective in the animals in preventive settings, but not in the therapeutic administration?
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spelling pubmed-94376022022-09-09 The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer Ye, Wei Ye, Chuantao Hu, Yongliang Dong, Yangchao Lei, Yingfeng Zhang, Fanglin Virol Sin Perspective • The structure of glycoprotein Gc, responsible for membrane fusion, is revealed, but many more mysteries remain. • Why do only antibodies against Gc have neutralizing effect, but not the one against Gn? • Why can NAbs against Gc only be protective in the animals in preventive settings, but not in the therapeutic administration? Wuhan Institute of Virology, Chinese Academy of Sciences 2022-05-14 /pmc/articles/PMC9437602/ /pubmed/35577043 http://dx.doi.org/10.1016/j.virs.2022.05.003 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Perspective
Ye, Wei
Ye, Chuantao
Hu, Yongliang
Dong, Yangchao
Lei, Yingfeng
Zhang, Fanglin
The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer
title The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer
title_full The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer
title_fullStr The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer
title_full_unstemmed The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer
title_short The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer
title_sort structure of crimean-congo hemorrhagic fever virus gc is revealed; many more still need an answer
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437602/
https://www.ncbi.nlm.nih.gov/pubmed/35577043
http://dx.doi.org/10.1016/j.virs.2022.05.003
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