STUB1 regulates antiviral RNAi through inducing ubiquitination and degradation of Dicer and AGO2 in mammals

RNA interference (RNAi) is an intrinsic antiviral immune mechanism conserved in diverse eukaryotic organisms. However, the mechanism by which antiviral RNAi in mammals is regulated is poorly understood. In this study, we uncovered that the E3 ubiquitin ligase STIP1 homology and U-box-containing prot...

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Detalles Bibliográficos
Autores principales: Zhang, Shumin, Zhang, Xuhua, Bie, Yuanyuan, Kong, Jing, Wang, An, Qiu, Yang, Zhou, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437610/
https://www.ncbi.nlm.nih.gov/pubmed/35533808
http://dx.doi.org/10.1016/j.virs.2022.05.001

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