Avoiding entry into intracellular protein degradation pathways by signal mutations increases protein secretion in Pichia pastoris

In our previous study, we serendipitously discovered that protein secretion in the methylotrophic yeast Pichia pastoris is enhanced by a mutation (V50A) in the mating factor alpha (MFα) prepro‐leader signal derived from Saccharomyces cerevisiae. In the present study, we investigated 20 single‐amino‐...

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Detalles Bibliográficos
Autores principales: Ito, Yoichiro, Ishigami, Misa, Hashiba, Noriko, Nakamura, Yasuyuki, Terai, Goro, Hasunuma, Tomohisa, Ishii, Jun, Kondo, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437885/
https://www.ncbi.nlm.nih.gov/pubmed/35656803
http://dx.doi.org/10.1111/1751-7915.14061

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