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PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization
Posttraumatic Stress Disorder (PTSD) symptomatology is associated with dysregulated sustained attention, which produces functional impairments. Performance on sustained attention paradigms such as continuous performance tasks are influenced by both the ability to sustain attention and response strat...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437905/ https://www.ncbi.nlm.nih.gov/pubmed/36055063 http://dx.doi.org/10.1016/j.nicl.2022.103146 |
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author | Evans, Travis C. Alonso, Marina Rodriguez Jagger-Rickels, Audreyana Rothlein, David Zuberer, Agnieszka Bernstein, John Fortier, Catherine B. Fonda, Jennifer R. Villalon, Audri Jorge, Ricardo Milberg, William McGlinchey, Regina DeGutis, Joseph Esterman, Michael |
author_facet | Evans, Travis C. Alonso, Marina Rodriguez Jagger-Rickels, Audreyana Rothlein, David Zuberer, Agnieszka Bernstein, John Fortier, Catherine B. Fonda, Jennifer R. Villalon, Audri Jorge, Ricardo Milberg, William McGlinchey, Regina DeGutis, Joseph Esterman, Michael |
author_sort | Evans, Travis C. |
collection | PubMed |
description | Posttraumatic Stress Disorder (PTSD) symptomatology is associated with dysregulated sustained attention, which produces functional impairments. Performance on sustained attention paradigms such as continuous performance tasks are influenced by both the ability to sustain attention and response strategy. However, previous studies have not dissociated PTSD-related associations with sustained attention ability and strategy, which limits characterization of neural circuitry underlying PTSD-related attentional impairments. Therefore, we characterized and replicated PTSD-related associations with sustained attention ability and response strategy in trauma-exposed Veterans, which guided characterization of PTSD-related differences in neural circuit function. In Study 1, PTSD symptoms were selectively associated with reduced sustained attention ability, but not more impulsive response strategies. In Study 2, we utilized task and resting-state fMRI to characterize neural circuitry underlying PTSD-related differences in sustained attention ability. Both PTSD symptomatology and sustained attention ability exhibited converging associations with reduced dorsal attention network (DAN) synchronization to endogeneous attentional fluctuations. Post-hoc time course analyses demonstrated that PTSD symptoms were most accurately characterized by delayed, rather than globally reduced, DAN synchronization to endogenous attentional fluctuations. Together, these findings suggest that PTSD symptomatology may selectively impair sustained attention ability by disrupting proactive engagement of attentional control circuitry. |
format | Online Article Text |
id | pubmed-9437905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94379052022-09-03 PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization Evans, Travis C. Alonso, Marina Rodriguez Jagger-Rickels, Audreyana Rothlein, David Zuberer, Agnieszka Bernstein, John Fortier, Catherine B. Fonda, Jennifer R. Villalon, Audri Jorge, Ricardo Milberg, William McGlinchey, Regina DeGutis, Joseph Esterman, Michael Neuroimage Clin Regular Article Posttraumatic Stress Disorder (PTSD) symptomatology is associated with dysregulated sustained attention, which produces functional impairments. Performance on sustained attention paradigms such as continuous performance tasks are influenced by both the ability to sustain attention and response strategy. However, previous studies have not dissociated PTSD-related associations with sustained attention ability and strategy, which limits characterization of neural circuitry underlying PTSD-related attentional impairments. Therefore, we characterized and replicated PTSD-related associations with sustained attention ability and response strategy in trauma-exposed Veterans, which guided characterization of PTSD-related differences in neural circuit function. In Study 1, PTSD symptoms were selectively associated with reduced sustained attention ability, but not more impulsive response strategies. In Study 2, we utilized task and resting-state fMRI to characterize neural circuitry underlying PTSD-related differences in sustained attention ability. Both PTSD symptomatology and sustained attention ability exhibited converging associations with reduced dorsal attention network (DAN) synchronization to endogeneous attentional fluctuations. Post-hoc time course analyses demonstrated that PTSD symptoms were most accurately characterized by delayed, rather than globally reduced, DAN synchronization to endogenous attentional fluctuations. Together, these findings suggest that PTSD symptomatology may selectively impair sustained attention ability by disrupting proactive engagement of attentional control circuitry. Elsevier 2022-08-06 /pmc/articles/PMC9437905/ /pubmed/36055063 http://dx.doi.org/10.1016/j.nicl.2022.103146 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Evans, Travis C. Alonso, Marina Rodriguez Jagger-Rickels, Audreyana Rothlein, David Zuberer, Agnieszka Bernstein, John Fortier, Catherine B. Fonda, Jennifer R. Villalon, Audri Jorge, Ricardo Milberg, William McGlinchey, Regina DeGutis, Joseph Esterman, Michael PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
title | PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
title_full | PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
title_fullStr | PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
title_full_unstemmed | PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
title_short | PTSD symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
title_sort | ptsd symptomatology is selectively associated with impaired sustained attention ability and dorsal attention network synchronization |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437905/ https://www.ncbi.nlm.nih.gov/pubmed/36055063 http://dx.doi.org/10.1016/j.nicl.2022.103146 |
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