Cargando…

HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study

OBJECTIVE: The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and the Geriatric Nutrition Risk Index (GNRI) are used as prognostic factors in different types of cancers. In this study we analyzed the prognostic value of the HALP Score and the GNRI calculated prior to first-line treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: Güç, Zeynep Gülsüm, Alacacıoğlu, Ahmet, Kalender, Mehmet Eren, Oflazoğlu, Utku, Ünal, Sinan, Yıldız, Yaşar, Salman, Tarık, Küçükzeybek, Yüksel, Tarhan, Mustafa Oktay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437940/
https://www.ncbi.nlm.nih.gov/pubmed/36061883
http://dx.doi.org/10.3389/fnut.2022.905292
_version_ 1784781721557794816
author Güç, Zeynep Gülsüm
Alacacıoğlu, Ahmet
Kalender, Mehmet Eren
Oflazoğlu, Utku
Ünal, Sinan
Yıldız, Yaşar
Salman, Tarık
Küçükzeybek, Yüksel
Tarhan, Mustafa Oktay
author_facet Güç, Zeynep Gülsüm
Alacacıoğlu, Ahmet
Kalender, Mehmet Eren
Oflazoğlu, Utku
Ünal, Sinan
Yıldız, Yaşar
Salman, Tarık
Küçükzeybek, Yüksel
Tarhan, Mustafa Oktay
author_sort Güç, Zeynep Gülsüm
collection PubMed
description OBJECTIVE: The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and the Geriatric Nutrition Risk Index (GNRI) are used as prognostic factors in different types of cancers. In this study we analyzed the prognostic value of the HALP Score and the GNRI calculated prior to first-line treatment in patients diagnosed with de novo metastatic non-small cell lung cancer (mNSCLC). MATERIALS AND METHODS: De novo mNSCLC patients were retrospectively evaluated from January 2016 to December 2019. Patients with Driver’s mutation, severe comorbidities, active infection, or insufficient organ function, and those receiving anti-inflammatory treatment were excluded from the study. Optimal cut-off points for the HALP score and the GNRI were calculated with the receiver operating characteristic (ROC) curve analysis. Predictive factors for overall survival (OS) were assessed with univariate and multivariate Cox proportional hazard analyses, and OS was studied with the Kaplan–Meier analysis. RESULTS: The study included 401 patients in total. In the ROC curve analysis, the cut-off points were found 23.24 (AUC = 0.928; 95% CI: 0.901–0.955, p < 0.001) for HALP, and 53.60 (AUC = 0.932; 95% CI: 0.908–0.955, p < 0.001) for GNRI. Groups with lower HALP scores and lower GNRI had significantly shorter OS compared to those with higher HALP scores and GNRIs. Univariate analysis showed that male gender, smoking, high ECOG score, low HALP score and low GNRI were associated with worse survival rates. Multivariate analysis showed that low HALP score (HR = 2.988, 95% CI: 2.065–4.324, p < 0.001); low GNRI score (HR = 2.901, 95% CI: 2.045–4.114, p < 0.001) and smoking history (HR = 1.447, 95% CI: 1.046–2.001, p = 0.025) were independent factors associated with worse OS rates. CONCLUSION: Our study showed the HALP score and the GNRI to be of prognostic value as simple, cost-effective, and useful markers that predict OS in de novo mNSCLC patients.
format Online
Article
Text
id pubmed-9437940
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94379402022-09-03 HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study Güç, Zeynep Gülsüm Alacacıoğlu, Ahmet Kalender, Mehmet Eren Oflazoğlu, Utku Ünal, Sinan Yıldız, Yaşar Salman, Tarık Küçükzeybek, Yüksel Tarhan, Mustafa Oktay Front Nutr Nutrition OBJECTIVE: The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score and the Geriatric Nutrition Risk Index (GNRI) are used as prognostic factors in different types of cancers. In this study we analyzed the prognostic value of the HALP Score and the GNRI calculated prior to first-line treatment in patients diagnosed with de novo metastatic non-small cell lung cancer (mNSCLC). MATERIALS AND METHODS: De novo mNSCLC patients were retrospectively evaluated from January 2016 to December 2019. Patients with Driver’s mutation, severe comorbidities, active infection, or insufficient organ function, and those receiving anti-inflammatory treatment were excluded from the study. Optimal cut-off points for the HALP score and the GNRI were calculated with the receiver operating characteristic (ROC) curve analysis. Predictive factors for overall survival (OS) were assessed with univariate and multivariate Cox proportional hazard analyses, and OS was studied with the Kaplan–Meier analysis. RESULTS: The study included 401 patients in total. In the ROC curve analysis, the cut-off points were found 23.24 (AUC = 0.928; 95% CI: 0.901–0.955, p < 0.001) for HALP, and 53.60 (AUC = 0.932; 95% CI: 0.908–0.955, p < 0.001) for GNRI. Groups with lower HALP scores and lower GNRI had significantly shorter OS compared to those with higher HALP scores and GNRIs. Univariate analysis showed that male gender, smoking, high ECOG score, low HALP score and low GNRI were associated with worse survival rates. Multivariate analysis showed that low HALP score (HR = 2.988, 95% CI: 2.065–4.324, p < 0.001); low GNRI score (HR = 2.901, 95% CI: 2.045–4.114, p < 0.001) and smoking history (HR = 1.447, 95% CI: 1.046–2.001, p = 0.025) were independent factors associated with worse OS rates. CONCLUSION: Our study showed the HALP score and the GNRI to be of prognostic value as simple, cost-effective, and useful markers that predict OS in de novo mNSCLC patients. Frontiers Media S.A. 2022-08-18 /pmc/articles/PMC9437940/ /pubmed/36061883 http://dx.doi.org/10.3389/fnut.2022.905292 Text en Copyright © 2022 Güç, Alacacıoğlu, Kalender, Oflazoğlu, Ünal, Yıldız, Salman, Küçükzeybek and Tarhan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Güç, Zeynep Gülsüm
Alacacıoğlu, Ahmet
Kalender, Mehmet Eren
Oflazoğlu, Utku
Ünal, Sinan
Yıldız, Yaşar
Salman, Tarık
Küçükzeybek, Yüksel
Tarhan, Mustafa Oktay
HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study
title HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study
title_full HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study
title_fullStr HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study
title_full_unstemmed HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study
title_short HALP score and GNRI: Simple and easily accessible indexes for predicting prognosis in advanced stage NSCLC patients. The İzmir oncology group (IZOG) study
title_sort halp score and gnri: simple and easily accessible indexes for predicting prognosis in advanced stage nsclc patients. the i̇zmir oncology group (izog) study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437940/
https://www.ncbi.nlm.nih.gov/pubmed/36061883
http://dx.doi.org/10.3389/fnut.2022.905292
work_keys_str_mv AT guczeynepgulsum halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT alacacıogluahmet halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT kalendermehmeteren halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT oflazogluutku halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT unalsinan halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT yıldızyasar halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT salmantarık halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT kucukzeybekyuksel halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy
AT tarhanmustafaoktay halpscoreandgnrisimpleandeasilyaccessibleindexesforpredictingprognosisinadvancedstagensclcpatientstheizmironcologygroupizogstudy