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Pooled human bone marrow-derived mesenchymal stromal cells with defined trophic factors cargo promote dermal wound healing in diabetic rats by improved vascularization and dynamic recruitment of M2-like macrophages

Human Mesenchymal Stromal Cells (hMSCs) are a promising source for cell-based therapies. Yet, transition to phase III and IV clinical trials is remarkably slow. To mitigate donor variabilities and to obtain robust and valid clinical data, we aimed first to develop a manufacturing concept balancing l...

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Detalles Bibliográficos
Autores principales: Willer, Hélène, Spohn, Gabriele, Morgenroth, Kimberly, Thielemann, Corinna, Elvers-Hornung, Susanne, Bugert, Peter, Delorme, Bruno, Giesen, Melanie, Schmitz-Rixen, Thomas, Seifried, Erhard, Pfarrer, Christiane, Schäfer, Richard, Bieback, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9437960/
https://www.ncbi.nlm.nih.gov/pubmed/36059533
http://dx.doi.org/10.3389/fimmu.2022.976511