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Trem2 deletion enhances tau dispersion and pathology through microglia exosomes

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disorder that manifests sequential Aβ and tau brain pathology with age-dependent onset. Variants in the microglial immune receptor TREM2 are associated with enhanced risk of onset in sporadic Alzheimer’s disease (AD). While recent studies s...

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Detalles Bibliográficos
Autores principales:	Zhu, Bing, Liu, Yan, Hwang, Spring, Archuleta, Kailey, Huang, Huijie, Campos, Alex, Murad, Rabi, Piña-Crespo, Juan, Xu, Huaxi, Huang, Timothy Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438095/ https://www.ncbi.nlm.nih.gov/pubmed/36056435 http://dx.doi.org/10.1186/s13024-022-00562-8

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